诱导类凋亡的抗肿瘤化合物的研究进展

陈策, 孙小龙, 谢琦琦, 林修辉, 潘莉分, 胡琼莹

中国药学杂志 ›› 2022, Vol. 57 ›› Issue (18) : 1512-1517.

PDF(1757 KB)
PDF(1757 KB)
中国药学杂志 ›› 2022, Vol. 57 ›› Issue (18) : 1512-1517. DOI: 10.11669/cpj.2022.18.003
综述

诱导类凋亡的抗肿瘤化合物的研究进展

  • 陈策1,2, 孙小龙1, 谢琦琦1, 林修辉1, 潘莉分1, 胡琼莹1,2*
作者信息 +

Advance in Research on Compounds with Paraptosis Induction Effect

  • CHEN Ce1,2, SUN Xiao-long1, XIE Qi-qi1, LIN Xiu-hui1, PAN Li-fen1, HU Qiong-ying1,2*
Author information +
文章历史 +

摘要

如何克服因肿瘤细胞凋亡缺失或受阻出现的肿瘤耐药问题,是目前肿瘤治疗过程中亟需解决的难题之一,发现新的非凋亡细胞程序性死亡方式并运用相应作用机制的药物可作为肿瘤治疗的一种新策略。类凋亡是一种新的程序性细胞死亡方式,通常伴随着由内质网应激、蛋白酶体抑制或离子稳态失衡导致的细胞器肿胀,并且为非caspase依赖性的。笔者对细胞类凋亡的作用机制和诱导细胞类凋亡的化合物进行综述,并对该领域未来的研究方向进行探讨,以期为肿瘤治疗提供一种新思路。

Abstract

How to overcome the problem of drug resistance to tumors caused by the loss or obstruction of tumor cell apoptosis is one of the urgent problems to be solved in cancer treatment. It could be a new strategy for cancer treatment to discover a new programmed cell death of non-apoptosis and utilize the corresponding drugs with action mechanism described above. Paraptosis is a kind of new programmed cell death, which is usually accompanied by cytoplasmic vacuolation derived from endoplasmic reticulum stress, proteasome inhibition or ion homeostasis imbalance, and which is caspase independent. The current review outlined the mechanism of cell paraptosis and the compounds that induce cell paraptosis. Then, the trend in this field was discussed to offer a new idea for cancer treatment.

关键词

类凋亡 / 凋亡 / 化合物 / 抗肿瘤 / 内质网应激

Key words

paraptosis / apoptosis / compound / antitumor / endoplasmic reticulum stress

引用本文

导出引用
陈策, 孙小龙, 谢琦琦, 林修辉, 潘莉分, 胡琼莹. 诱导类凋亡的抗肿瘤化合物的研究进展[J]. 中国药学杂志, 2022, 57(18): 1512-1517 https://doi.org/10.11669/cpj.2022.18.003
CHEN Ce, SUN Xiao-long, XIE Qi-qi, LIN Xiu-hui, PAN Li-fen, HU Qiong-ying. Advance in Research on Compounds with Paraptosis Induction Effect[J]. Chinese Pharmaceutical Journal, 2022, 57(18): 1512-1517 https://doi.org/10.11669/cpj.2022.18.003
中图分类号: R961    R730.5   

参考文献

[1] ZHOU Y, HUANG F, YANG Y, et al. Paraptosis-inducing nanomedicine overcomes cancer drug resistance for a potent cancer therapy[J]. Small, 2018, 14(7): 1702446. Doi: 10.1002/smll.201702446.
[2] DING Q, ZHANG W, CHENG C, et al. Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo[J]. J Cell Physiol, 2020, 235(3): 2911-2924.
[3] LIU J, CAI W, FANG X, et al. Virus-induced apoptosis and phosphorylation form of metacaspase in the marine coccolithophorid Emiliania huxleyi[J]. Arch Microbiol, 2018,200(3):413-422.
[4] JUNG S, CHOE S, WOO H, et al. Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits[J]. Autophagy, 2020, 16(3): 512-530.
[5] NASS J, EFFERTH T. Insights into apoptotic proteins in chemotherapy: quantification techniques and informing therapy choice[J]. Expert Rev Proteomics, 2018,15(5):413-429.
[6] PFEFFER C M, SINGH A T K. Apoptosis: atarget for anticancer therapy[J]. Int J Mol Sci, 2018, 19(2): 448. Doi: 10.3390/ijms19020448.
[7] BLANK M, SHILOH Y. Programs for cell death: apoptosis is only one way to go[J]. Cell Cycle,2007,6(6):686-695.
[8] SPERANDIO S, DE BELL I, BREDESEN D E. An alternative, nonapoptotic form of programmed cell death[J]. Proc Natl Acad Sci USA,2000, 97(26):14376-14381.
[9] SUN Y, PENG Z L. Programmed cell death and cancer[J]. Postgrad Med J, 2009, 85(1001):134-140.
[10] HIRATA H, UTO-KONDO H, OGURA M, et al. Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport[J]. J Nutr Biochem, 2017, 47:29-34.
[11] CHEN Q, SONG S, WANG Z, et al. Isorhamnetin induces the paraptotic cell death through ROS and the ERK/MAPK pathway in OSCC cells[J]. Oral Dis, 2021, 27(2):240-250.
[12] KIST M, VUCIC D. Cell death pathways: intricate connections and disease implications[J]. EMBO J, 2021, 40(5):e106700. Doi: 10.15252/embj.2020106700.
[13] KAUFMANN S H, EARNSHAW W C. Induction of apoptosis by cancer chemotherapy[J]. Exp Cell Res, 2000, 256(1):42-49.
[14] BURY M, GIRAULT A, MEGALIZZI V, et al. Ophiobolin a induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity[J]. Cell Death Dis, 2013, 4(3):e561.Doi: 10.1038/cddis.2013.85.
[15] SPERANDIO S, POKSAY K, DE-BELLE I, et al. Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix[J]. Cell Death Differ,2004, 11(10):1066-1075.
[16] WANG S, GUO Y, YANG C, et al. Swainsonine triggers paraptosis via ER stress and MAPK signaling pathway in rat primary renal tubular epithelial cells[J]. Front Pharmacol, 2021, 12:715285. Doi: 10.3389/fphar.2021.715285.
[17] PENG Y, GUO C, YANG Y, et al. Baicalein induces apoptosis of human cervical cancer HeLa cells in vitro[J]. Mol Med Rep, 2015, 11(3):2129-2134.
[18] ZHENG H, DONG Y, LI L, et al. Novel benzo[a]quinolizidine analogs induce cancer cell death through paraptosis and apoptosis[J]. J Med Chem, 2016, 59(10):5063-5076.
[19] RAIMONDI M, FONTANA F, MARZAGALLI M, et al. Ca2+ overload- and ROS-associated mitochondrial dysfunction contributes to delta-tocotrienol-mediated paraptosis in melanoma cells[J]. Apoptosis, 2021, 26(5-6):277-292.
[20] MI X Q, WANG C M, SUN C, et al. Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway[J]. Oncotarget,2017, 8(19):31297-31304.
[21] YUMNAM S, PARK H S, KIM M K, et al. Hesperidin induces paraptosis like cell death in hepatoblastoma, HepG2 cells: involvement of ERK1/2 MAPK[J]. PLoS One,2014, 9(6):e101321. Doi: 10.1371/journal.pone.0101321.
[22] YUMNAM S, HONG G E, RAHA S, et al. Mitochondrial dysfunction and Ca2+ overload contributes to hesperidin induced paraptosis in hepatoblastoma cells, HepG2[J]. J Cell Physiol, 2016, 231(6):1261-1268.
[23] ZHU D, CHEN C, XIA Y, et al. A purified resin glycoside fraction from pharbitidis semen induces paraptosis by activating chloride intracellular channel-1 in human colon cancer cells[J]. Integr Cancer Ther, 2019, 18:1534735418822120. Doi: 10.1177/1534735418822120.
[24] WANG Y, ZHU X, YANG Z, et al. Honokiol induces caspase-independent paraptosis via reactive oxygen species production that is accompanied by apoptosis in leukemia cells[J]. Biochem Biophys Res Commun, 2013, 430(3):876-882.
[25] LIU X, GU Y, BIAN Y, et al. Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation[J]. Apoptosis, 2021, 26(3-4):195-208.
[26] FONTANA F, RAIMONDI M, MARZAGALLI M, et al. Mitochondrial functional and structural impairment is involved in the antitumor activity of delta-tocotrienol in prostate cancer cells[J]. Free Radic Biol Med,2020, 160:376-390.
[27] DAI C H, ZHU L R, WANG Y, et al. Celastrol acts synergistically with afatinib to suppress non-small cell lung cancer cell proliferation by inducing paraptosis[J]. J Cell Physiol, 2020, 236(6): 4538-4554.
[28] CHEN X, CHEN X M, ZHANG X, et al. Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells[J]. Redox Biol, 2019, 21:101061. Doi: 10.1016/j.redox.2018.11.019.
[29] GARRIDO-ARMAS M, CORONA JC, ESCOBAR ML, et al. Paraptosis in human glioblastoma cell line induced by curcumin[J]. Toxicol In Vitro, 2018, 51:63-73.
[30] PANG H F, LI X X, ZHAO Y H, et al. Confirming whether novel rhein derivative 4a induces paraptosis-like cell death by endoplasmic reticulum stress in ovarian cancer cells[J]. Eur J Pharmacol, 2020, 886:173526. Doi: 10.1016/j.ejphar.2020.173526.
[31] YOKOI K, BALACHANDRAN C, UMEZAWA M, et al. Amphiphilic cationic triscyclometalated iridium(III) complex-peptide hybrids induce paraptosis-like cell death of cancer cells via an intracellular Ca2+-Dependent Pathway[J]. ACS Omeg, 2020, 5(12):6983-7001.
[32] DEMAIN A L, VAISHNAV P. Natural products for cancer chemotherapy[J]. Microb Biotechnol,2011, 4(6):687-699.
[33] WANG Y, WEN X, ZHANG N, et al. Small-molecule compounds target paraptosis to improve cancer therapy[J]. Biomed Pharmacother, 2019, 118:109203. Doi: 10.1016/j.biopha.2019.109203.
[34] GUO D L, ZHANG B G, LIU S Q, et al. Xanthohumol induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI3K/Akt/mTOR-kinase in human gastric cancer cells[J]. Biomed Pharmacother,2018,106:1300-1306.
[35] ZHAO X, JIANG K, LIANG B, et al. Anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-kappaB/p53-apoptosis signaling pathway[J]. Oncol Rep, 2016, 35(2):669-675.
[36] LI F, YAO Y Y, HUANG H, et al. Xanthohumol attenuates cisplatin-induced nephrotoxicity through inhibiting NF-kappaB and activating Nrf2 signaling pathways[J]. Int Immunopharmacol,2018, 61:277-282.
[37] HU S, HUANG L, MENG L, et al. Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogenactivated protein kinase kinase signaling pathways[J]. Mol Med Rep, 2015, 12(5):6745-6751.
[38] SUN J, SUN G, MENG X, et al. Isorhamnetin protects against doxorubicin-induced cardiotoxicity in vivo and in vitro[J]. PLoS One, 2013, 8(5):e64526. Doi: 10.1371/journal. pone. 0064 526.
[39] LEE C J, WILSON L, JORDAN M A, et al. Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cells[J]. Phytother Res, 2010, 24(Suppl 1):S15-S19.
[40] SUGAWARAF,STROBELG, STRANGERN, et al. Phytotoxins from the pathogenic fungi Drechslera maydis and Drechslera sorghicola[J]. Proc Natl Acad Sci USA, 1987, 84(10):3081-3085.
[41] KIM I Y, KWON M, CHOI M K, et al. Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis[J]. Oncotarget, 2017, 8(63):106740-106752.
[42] CHENG L, CHEN Q, PI R, et al. A research update on the therapeutic potential of rhein and its derivatives[J]. Eur J Pharmacol, 2021, 899:173908. Doi: 10.1016/j.ejphar.2021.173908.
[43] LIU S, WANG J, SHAO T, et al. The natural agent rhein induces beta-catenin degradation and tumour growth arrest[J]. J Cell Mol Med, 2018, 22(1):589-599.
[44] LEE D, KIM I Y, SAHA S, et al. Paraptosis in the anti-cancer arsenal of natural products[J]. Pharmacol Ther, 2016, 162:120-133.
[45] XIONG Z, YUAN C, SHI J, et al. Restoring the epigenetically silenced PCK2 suppresses renal cell carcinoma progression and increases sensitivity to sunitinib by promoting endoplasmic reticulum stress[J]. Theranostics, 2020, 10(25):11444-11461.
[46] HOTAMISLIGIL G S, DAVIS R J. Cell signaling and stress responses[J]. Cold Spring Harb Perspect Biol, 2016, 8(10):a006072. Doi: 10.1101/cshperspect.a006072.
[47] JIN J, MA Y, TONG X, et al. Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK[J]. Hum Reprod, 2020, 35(5):1145-1158.
[48] SHEN K, JOHNSON D W, VESEY D A, et al. Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies[J]. Cell Stress Chaperones, 2018, 23(3):317-334.
[49] APPENZELLER-HERZOG C, HALL MN. Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling[J]. Trends Cell Biol, 2012, 22(5):274-282.
[50] NOROUZI S, MAJEED M, PIRRO M, et al. Curcumin as an adjunct therapy and microRNA modulator in breast cancer[J]. Curr Pharm Des, 2018, 24(2):171-177.
[51] YOON M J, KIM E H, LIM J H, et al. Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells[J]. Free Radic Biol Med, 2010, 48(5):713-726.
[52] YOON M J, KIM E H, KWON T K, et al. Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells[J]. Cancer Lett, 2012, 324(2):197-209.
[53] BRAVO R, GUTIERREZ T, PAREDES F, et al. Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics[J]. Int J Biochem Cell Biol, 2012, 44(1):16-20.
[54] CAO S S, KAUFMAN R J. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease[J]. Antioxid Redox Signal, 2014, 21(3):396-413.
[55] YOON M J, LEEL A R, JEONG S A, et al. Release of Ca2+ from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells[J]. Oncotarget, 2014, 5(3):6816-6830.
[56] DHILLON A S, HAGAN S, RATH O, et al. MAP kinase signalling pathways in cancer[J]. Oncogene, 2007, 26(22):3279-3290.
[57] WAGNER E F, NEBREDA A R. Signal integration by JNK and p38 MAPK pathways in cancer development[J]. Nat Rev Cancer, 2009, 9(8):537-549.
[58] MARTINI M, DE SANTIS M C, BRACCINI L, et al. PI3K/AKT signaling pathway and cancer: an updated review[J]. Ann Med, 2014, 46(6):372-383.
[59] ALZAHRANI A S. PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside[J]. Semin Cancer Biol,2019,59:125-132.
[60] PELUSO I, YARLA N S, AMBRA R, et al. MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents[J]. Semin Cancer Biol, 2019, 56:185-195.
[61] SUN Q, CHEN T, WANG X, et al. Taxol induces paraptosis independent of both protein synthesis and MAPK pathway[J]. J Cell Physiol,2010,222(2):421-432.

基金

浙江省基础公益项目资助(LGF21H280002);浙江省公益技术应用研究项目资助(2016C37143)
PDF(1757 KB)

Accesses

Citation

Detail

段落导航
相关文章

/