Chemical Constituents from Bulbils of Dioscorea Opposite Thunb
LIU Yan-ling1,2, GUO Meng-huan1,2,CAO Yan-gang1,2, REN Ying-jie1,2, WANG Meng-na1,2, ZHENG Xiao-ke1,2, FENG Wei-sheng1,2*
1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China;
2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046,China
OBJECTIVE To investigate the chemical constituents from the bulbils of Dioscorea opposite Thunb. METHODS The chemical constituents were isolated and identified by various separation techniques such as silica gel, Toyopreal HW-40C,Sephadex LH-20,MCI gel CHP-20, ODS and preparative HPLC.Their structures were elucidated by analysis of physicochemical properties and spectroscopic evidence. RESULTS Sixteen compounds were isolated and identified as vomifoliol(1), roseoside(2),phenethyl-8-O-β-D-glucopyranoside(3), artselaeroside A(4),benzyl-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside(5), seguinoside E(6),dioscorolide A(7),apigenin(8),5,7-dihydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone(9), 2,7-dihydroxy-4,6-dimethoxyphenanthrene(10),4-hydroxyacetophenone(11),2-hydroxy-3,5,7-trimethoxy-9,10-dihydrophenanthrene(12), rhododendrol(13), 3-methoxy-4-hydroxyphenethyl alcohol(14), 3,5-dimethoxy-4-hydroxyphenethyl alcohol(15), and 4-(3,4-dihydroxyphenyl)-2-butanone(16). CONCLUSION Compounds 2-6, 9 and 11-16 are isolated from genus Dioscorea for the first time, and the other compounds are isolated from this plant for the first time.
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2022, Vol. 57 
