Research Progress of Novel Nano-Drug Delivery Systems for Cancer Treatment
CHEN Jie1, CAO Ye2, LI Shuang-shuang1, LUO Lai-long1, YU Peng1*, LI Ming-yuan1*
1. College of Biotechnology, Tianjin University of Science & Technology, Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid, Tianjin 300457, China; 2. Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China
Abstract：Nano-drug delivery system is a promising drug delivery strategy, and its outstanding advantages are more and more valued by the medical community, especially in the field of cancer treatment. Nano-drug delivery system can not only improve the specific effect on tumor tissues by changing the pharmacokinetics and tissue distribution of drugs, but also reduce the toxicity of drugs to normal tissues while inhibiting tumor growth. In recent years, scientists have been working to improve nanomedicine delivery systems using new technologies, including nanocrystal, nanoparticles, nanorobot and nanozyme. This review will highlight recent research of nano-drug delivery system.
陈洁, 曹晔, 李双双, 罗来龙, 郁彭, 李明媛. 针对肿瘤的新型纳米药物递送系统研究进展[J]. 中国药学杂志, 2020, 55(21): 1749-1756.
CHEN Jie, CAO Ye, LI Shuang-shuang, LUO Lai-long, YU Peng, LI Ming-yuan. Research Progress of Novel Nano-Drug Delivery Systems for Cancer Treatment. Chinese Pharmaceutical Journal, 2020, 55(21): 1749-1756.
SUN M, QIAN Q, SHI L, et al. Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs[J]. Sci China Chem(中国科学 化学), 2020, 63(1):35-41.
[2]
KUMSTEL S, VASUDEVAN P, PALME R, et al. Benefits of non-invasive methods compared to telemetry for distress analysis in a murine model of pancreatic cancer[J]. J Adv Res, 2020, 21:35-47.
[3]
LIANG B, ZHAO D, LIU Y, et al. Chemoembolization of liver cancer with doxorubicin-loaded Calli Spheres microspheres: plasma pharmacokinetics, intratumoral drug concentration, and tumor necrosis in a rabbit model[J]. Drug Deliv Transll Res, 2020, 10(1):185-191.
[4]
GOOS J A C M, CHO A, CARTER L M, et al. Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect[J]. Theranostics, 2020, 10(2):567-584.
[5]
FERREIRA L L, CERVANTES M, FROUFE H J C, et al. Doxorubicin persistently rewires cardiac circadian homeostasis in mice[J]. Arch Toxicol, 2020, 94(1):257-271.
[6]
PUTTHIKORN S, RUENGROT P, BAOWAN D. Energy behaviour of doxorubicin interacting with peptide nanotubes[J]. J Math Chem, 2020, 58(2):382-392.
[7]
DARRELL J I, ERIC L D. Enhancing cancer immunotherapy with nanomedicine[J]. Nat Rev Immunol, 2020, 20(5):321-334.
[8]
SHENGPING Z, DIAN W, JINGYING H, et al. Application of capsaicin as a potential new therapeutic drug in human cancers[J]. J Clin Pharm Ther, 2019,45(8):1-13.
[9]
MARTIN J D, CABRAL H, STYLIANOPOULOS T, et al. Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges[J]. Nat Rev Clin Oncol, 2020, 17(4):251-266.
[10]
KAMALY N, YAMEEN B, WU J, et al. Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release[J]. Chem Rev, 2016, 116(4):2602-2663.
[11]
BOBO D, ROBINSON K J, ISLAM J, et al. Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date[J]. Pharm Res, 2016, 33(10):2373-2387.
[12]
BLANCO E, SHEN H, FERRARI M. Principles of nanoparticle design for overcoming biological barriers to drug delivery[J]. Nat Biotechnol, 2015, 33(9):941-951.
[13]
YAN D, LEI B, CHEN B, et al. Synthesis of high-quality lanthanide oxybromides nanocrystals with single-source precursor for promising applications in cancer cells imaging[J]. Appl Mater Today, 2015, 1(1):20-26.
[14]
BI D, ZHAO L, ZHAO X, et al. Preparation of polydopamine-based hydroxycamptothecin nanocrystals for potential osteosarcoma treatment[J]. Chin J New Drugs(中国新药杂志),2018, 27(13):1549-1554.
[15]
ZHANG C, ZHANG S, ZHI D, et al. Co-delivery of paclitaxel and survivin siRNA with cationic liposome for lung cancer therapy[J]. Colloids Surfaces A-Physicochem Eng Aspec, 2020,585:124054.
[16]
HUANG Z G, LV F M, WANG J, et al. RGD-modified PEGylated paclitaxel nanocrystals with enhanced stability and tumor-targeting capability[J]. Int J Pharm, 2019, 556:217-225.
[17]
LOW L E, TAN L T H, GOH B H, et al. Magnetic cellulose nanocrystal stabilized pickering emulsions for enhanced bioactive release and human colon cancer therapy[J]. Int J Biol Macromol, 2019, 127:76-84.
[18]
CHEN J, MAO L, QI H, et al. Preparation of fluorescent cellulose nanocrystal polymer composites with thermo-responsiveness through light-induced ATRP[J]. Cellulose, 2020, 27(2):743-753.
[19]
NA L. Rod-like cellulose nanocrystals are acid-sensitive nanomedicines[D]. East China Normal University, 2019.
[20]
BENJAMIN R, CHRISTELLE P, GAUTIER M A N N, et al. Enhancement of hydrosolubility and in vitro antiproliferative properties of chalcones following encapsulation into β-cyclodextrin/cellulose-nanocrystal complexes[J]. Bioorg Med Chem Lett, 2019, 29(15):1895-1898.
[21]
SHIEKHZADEH A, SOHRABI N, MOGHADAM M E, et al. Kinetic and thermodynamic investigation of human serum albumin interaction with anticancer glycine derivative of platinum complex by using spectroscopic methods and molecular docking[J]. Appl Biochem Biotechnol, 2020, 190(2):506-528.
[22]
PARK J, SUN B, YEO Y. Albumin-coated nanocrystals for carrier-free delivery of paclitaxel[J]. J Controlled Release, 2017, 263:90-101.
[23]
PARK J E, PARK J, JUN Y, et al. Expanding therapeutic utility of carfilzomib for breast cancer therapy by novel albumin-coated nanocrystal formulation[J]. J Controlled Release, 2019, 302:148-159.
[24]
LIU J, TU L, CHENG M, et al. Mechanisms for oral absorption enhancement of drugs by nanocrystals[J]. J Drug Deliv Sci Technol, 2020, 56:101607.
[25]
IMONO M, UCHIYAMA H, YOSHIDA S, et al. The elucidation of key factors for oral absorption enhancement of nanocrystal formulations: in vitro-in vivo correlation of nanocrystals[J]. Eur J Pharm Biopharm, 2020, 146:84-92.
[26]
YUEQIN M A, ZHANG Z Z, GANG L I, et al. Advances in nanocrystal technology and its application in targeted drug delivery[J]. Chin J Hosp Pharm(中国医院药学杂志), 2018, 38(9):1014-1017.
[27]
YU X, SUN L, TAN L, et al. Preparation and characterization of PLGA-PEG-PLGA nanoparticles containing salidroside and tamoxifen for breast cancer therapy[J]. AAPS Pharm Sci Tech, 2020, 21(3):85-96.
[28]
SIBI R, SARTAJ K, RAMESH C, et al. Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy[J]. Semin Cancer Biol, 2019,11(9):523-537.
[29]
KHAN H, MIRZAEI H R, AMIRI A, et al. Glyco-nanoparticles: new drug delivery systems in cancer therapy[J]. Semin Cancer Biol, 2019,12(4):276-295.
[30]
HAN Y, HU B, WANG M, et al. pH-Sensitive tumor-targeted hyperbranched system based on glycogen nanoparticles for liver cancer therapy[J]. Appl Mater Today, 2020,18:100521.
[31]
LI R, HE Y, ZHANG S, et al. Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment[J]. Acta Pharm Sin B(药学学报英文), 2018, 8(1):14-22.
[32]
HUANG J W, JIANG C Y, LUO Y Y, et al. A novel drug delivery system—red blood cell membranes biomimetic nanoparticles[J]. J Sun Yat-sen Univ Nat Sci Ed(中山大学学报 自然科学版), 2019, 58(5):114-118.
[33]
KAN X B. Shanghai Institute of Materia Medica, Chinese Academy of Sciences discovered that tumor-selective bionic nanoparticles can inhibit breast cancer in situ tumor growth and lung metastasis[J]. Cap Food Med(首都食品与医药),2018,25(8):5
[34]
LIU C M, CHEN G B, CHEN H H, et al. Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment[J]. Colloids Surfaces B-Biointerfaces, 2019, 175:477-486.
[35]
JIANG Q, LIU Y, GUO R, et al. Erythrocyte-cancer hybrid membrane-camouflaged melanin nanoparticles for enhancing photothermal therapy efficacy in tumors[J]. Biomaterials, 2019, 192:292-308.
[36]
XIA Y, XIA Q, CUI H, et al. Homologous membrane coated intelligent drug release nanoparticles for targeted therapy of liver cancer[J]. Appl Chem, 2020, 37(1):69-79.
[37]
YANG R, XU J, XU L, et al. Cancer cell membrane-coated adjuvant nanoparticles with mannose modification for effective anticancer vaccination[J]. Acs Nano, 2018, 12(6):5121-5129.
[38]
XIA Q, ZHANG Y, LI Z, et al. Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application[J]. Acta Pharm Sin B(药学学报英文), 2019, 9(4):675-689.
[39]
XU C H, YE P J, ZHOU Y C, et al. Cell membrane-camouflaged nanoparticles as drug carriers for cancer therapy[J]. Acta Biomater, 2020, 105:1-14.
[40]
LUK B T, ZHANG L. Cell membrane-camouflaged nanoparticles for drug delivery[J]. J Controlled Release, 2015, 220:S0168365915300328.
[41]
CUI L, GUO T T, YU L. Research progress of different binding biomimetic nanoparticles[J]. Chin J Clin Pharmacol, 2018, 34(1):81-84.
[42]
KANG T, KIM Y G, KIM D, et al. Inorganic nanoparticles with enzyme-mimetic activities for biomedical applications[J]. Coord Chem Rev, 2020, 403:213092.
[43]
JANG E H, KIM G L, PARK M G, et al. Hypoxia-responsive, organic-inorganic hybrid mesoporous silica nanoparticles for triggered drug release[J]. J Drug Deliv Sci Technol, 2020, 56:101543.
[44]
ELZOGHBY A O, HEMASA A L, FREAG M S. Hybrid protein-inorganic nanoparticles: from tumor-targeted drug delivery to cancer imaging[J]. J Controlled Release, 2016, 243:303-322.
[45]
PUGAZHENDHI A, EDISON T N J I, KARUPPUSAMY I, et al. Inorganic nanoparticles: a potential cancer therapy for human welfare[J]. Int J Pharm, 2018, 539(1-2):104-111.
[46]
GAO J L, GONG J B, LIU Y M, et al. Study on the modification of Fe3O4 nanoparticles with -cyclodextrin for drug delivery system[J]. Mod Chem Ind, 2019,40(2):157-161.
[47]
NEHRU S, SAKTHINATHAN S, TAMIZHDURAI P, et al. Reduced graphene oxide/multiwalled carbon nanotube composite decorated with Fe3O4 magnetic nanoparticles for electrochemical determination of hydrazine in environmental water[J]. J Nanosci Nanotechnol, 2020, 20(5):3148-3156.
[48]
DING Y, GUO H, GE W, et al. Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide b-triazole conjugates and their anti-cancer activities[J]. Eur J Med Chem, 2018, 156:216-229.
[49]
WU D, WANG W, HE X, et al. Biofabrication of nano copper oxide and its aptamer bioconjugate for delivery of mRNA 29b to lung cancer cells[J]. Mater Sci Eng C-Mater Biol Appl, 2019, 97:827-832.
[50]
REN Q. Effect of Cuprous oxide nanoparticles (CONPs) on bladder urothelial carcinoma[D]. Shanghai:PLA Naval Medical University,2018.
[51]
YU B. Inhibition and killing of human melanoma stem cells by Cuprous oxide nanoparticles (CONPs)[D]. Shanghai:Second Military Medical University,2016.
[52]
XIA L. Treatment and mechanism of cuprous oxide nanoparticles for cervical cancer[D]. Shanghai: Second Military Medical University, 2017.
[53]
KUMAR A, RATHI E, KINI S G. Drug repurposing approach for the identification and designing of potential E6 inhibitors against cervical cancer: an in silico investigation[J]. Struct Chem, 2020, 31(1):141-153.
[54]
PIERETTI J C, ROLIM W R, FERREIRA F F, et al. Synthesis, characterization, and cytotoxicity of Fe3O4@Ag hybrid nanoparticles: promising applications in cancer treatment[J]. J Cluster Sci, 2020, 31(2):535-547.
[55]
SUNDRARAMAN G, JAYAKUMARI L S. Meticulous taxifolin releasing performance by the zinc oxide nanoparticles: as a short road to drug delivery system for cancer therapeutics[J]. J Cluster Sci, 2020, 31(1):241-255.
[56]
AHAMED M, AKHTAR M J, ALHADLAQ H A, et al. Copper ferrite nanoparticle-induced cytotoxicity and oxidative stress in human breast cancer MCF-7 cells[J]. Colloids Surfaces B-Biointerfaces, 2016, 142:46-54.
[57]
HAMZELOU, JESSICA. DNA origami nanorobot takes drug direct to cancer cell[J]. New Sci, 2012, 213(2853):9.
[58]
LI S, JIANG Q, DING B, et al. Anticancer activities of tumor-killing nanorobots[J]. Trends Biotechnol, 2019, 37(6):573-577.
[59]
CHO H S, WOO T H. Conceptual design of nano-robotics for carrying the radioisotope material in nuclear industry[J]. Ann Nucl Energy, 2015, 80:429-433.
[60]
"Intelligent DNA nanobots for cancer treatment" was selected as one of the top 10 scientific advances in China in 2018[J]. Cancer Res Prey Treat, 2019, 46(4):387.
[61]
ZHANG Y L, LI S P, JIANG Q, et al. An intelligent DNA nanorobot for tumor vascular embolization therapy[J]. Chin Sci Bull, 2019, (25):2625-2632.
[62]
SINGH H R, KOPPERGER E, SIMMEL F C. A DNA nanorobot uprises against cancer[J]. Trends Mol Med, 2018, 24(7):591-593.
[63]
TRIPATHI R, KUMAR A. Application of nanorobotics for cancer treatment[J]. Maters Today Proc, 2018, 5(3):9114-9117.
[64]
Nanobots developed by Chinese scientists are expected to be a new treatment for cancer[J]. Chin Cancer Clin Rehabil(中国肿瘤临床与康复), 2019,26(1):53.
[65]
BALA, PRABHAKAR, PRAVIN, et al. Current trends and emerging diagnostic techniques for lung cancer[J]. Biomed Pharmacother, 2018,106:1586-1599.
[66]
PENG T, DENG Z, HE J, et al. Functional nucleic acids for cancer theranostics[J]. Coord Chem Rev, 2020, 403:213080.
[67]
PENG R, ZHENG X, LYU Y, et al. Engineering a 3D DNA-logic gate nanomachine for bispecific recognition and computing on target cell surfaces[J]. J Am Chem Soc, 2018, 140(31):9793-9796.
[68]
MAHESWARI R, SHEEBA RANI S, GOMATHY V, et al. Cancer detecting nanobot using positron emission tomography[J]. Proc Comp Sci, 2018, 133:315-322.
[69]
WANG X. Briefly description of the research progress of precision medicine in cancer treatment[J]. Rural Econom Sci Technol, 2017, 28(14):283.
[70]
FENG L, DONG Z, LIANG C, et al. Iridium nanocrystals encapsulated liposomes as near-infrared light controllable nanozymes for enhanced cancer radiotherapy[J]. Biomaterials, 2018, 181:81-91.
[71]
GAO F, WU J, GAO H, et al. Hypoxia-tropic nanozymes as oxygen generators for tumor-favoring theranostics[J]. Biomaterials, 2020, 230:119635.
[72]
FAN K, XI J, FAN L, et al. In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy[J]. Nat Commun, 2018, 9(1):1440-1440.
[73]
ZENG L, HUANG K, WAN Y, et al. Programmed hunger and photodynamic synergetic cancer therapy[J]. Sci China Mater, 2019,15(12):1-9.
[74]
WANG Z Q. Application of ferric phosphate REDOX nanase in tumor oxidative stress therapy[D]. Qingdao:Qingdao University of Science and Technology,2019.
[75]
ZHANG L, WANG Z, ZHANG Y, et al. Erythrocyte membrane cloaked metal-organic framework nanoparticle as biomimetic nanoreactor for starvation-activated colon cancer therapy[J]. Acs Nano, 2018, 12(10):10201-10211.
[76]
CAO F. The design of a new generation of nanometer enzyme and its biological application[D]. Hefei: China Science & Technology University, 2019.
[77]
JOLANTA K, BARTOSZ K, LESZEK K. Correction to: glioblastoma multiforme: another potential application for 68Ga-PSMA PET/CT as a guide for targeted therapy[J]. Eur J Nucl Med Mol Imag, 2019, 47(2):886-887.
[78]
MA X, REN X, GUO X,et al. Multifunctional iron-based metal-organic framework as biodegradable nanozyme for microwave enhancing dynamic therapy[J]. Biomaterials, 2019, 214:119223.
[79]
XU Q. Design of biosensor based on nucleic acid probe and nanometer enzyme and its application in detection of cancer markers[D]. Wuhan: Huazhong University of Science and Technology, 2019.
[80]
LI Z, SUN Y, QIAN Q J. Targeted immunotherapy may become a key strategy to cure cancer[J]. Chin J Cancer Biother(中国肿瘤生物治疗杂志), 2019, 26(1):13-21.
[81]
HU X, XIA B, BAO Y,et al. Timing of thoracic radiotherapy is more important than dose intensification in patients with limited-stage small cell lung cancer: a parallel comparison of two prospective studies (vol 196, pg 172, 2020)[J]. Strahlenther Onkol,2020,196(4):405-405.
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