Progress of Brain Slice Culture Technology and Its Application in Drug Research and Development
LI Wei-han, WANG Yue-hua*, DU Guan-hua*
Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Abstract：Brain slice culture is an important experimental technique for studying the molecular mechanism and electrophysiological activities of brain ex vivo. It is also an important tool for studying the physiological and pathological processes in brain. Recently, with the continuous improvement of brain slice culture technology and detection methods, the survival time of brain slices has been greatly prolonged, monitoring methods have become more diversified, and the application of brain slice culture technology has been expanding in biomedical field. In this article, the progress of brain slice culture technology is reviewed. The application of brain slice culture technology in the establishment of neurological disease model and drug development is discussed. Brain slice culture technology is of great significance to neuroscience research and drug development.
李伟瀚, 王月华, 杜冠华. 脑片培养技术及其在药物研发中的应用进展[J]. 中国药学杂志, 2020, 55(13): 1068-1071.
LI Wei-han, WANG Yue-hua, DU Guan-hua. Progress of Brain Slice Culture Technology and Its Application in Drug Research and Development. Chinese Pharmaceutical Journal, 2020, 55(13): 1068-1071.
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2020, Vol. 55 
