硫酸软骨素的结构及其在骨关节炎治疗中的应用

何兆雄 金艳 张天民

中国药学杂志 ›› 2012, Vol. 47 ›› Issue (5) : 387-390.

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中国药学杂志 ›› 2012, Vol. 47 ›› Issue (5) : 387-390.
药物与临床

硫酸软骨素的结构及其在骨关节炎治疗中的应用

  • 何兆雄1,金艳2,张天民2
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Structure of Chondroitin Sulfate and Its Application in Osteoarthritis Therapy

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摘要

目的 综述硫酸软骨素(CS)的结构及其在骨关节炎(OA)中的应用。方法 通过检索近期文献,结合笔者实践,进行整理和分析。结果与结论 CS结构具有高度的不均一性。在欧洲,CS被推荐为缓解OA的症状慢作用药物;在美国,CS主要用作针对OA的膳食补充剂。CS对关节软骨的修复和保护作用,在于其能促进软骨细胞的合成代谢功能, 促进细胞外基质(ECM)结构组分的合成、更新;同时抑制分解代谢功能,抑制酶对ECM组分的降解作用。

关键词

硫酸软骨素 / 硫酸皮肤素 / 糖胺聚糖 / 骨关节炎

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何兆雄 金艳 张天民 . 硫酸软骨素的结构及其在骨关节炎治疗中的应用[J]. 中国药学杂志, 2012, 47(5): 387-390
Structure of Chondroitin Sulfate and Its Application in Osteoarthritis Therapy[J]. Chinese Pharmaceutical Journal, 2012, 47(5): 387-390

参考文献


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