血管内皮细胞与平滑肌细胞体外共培养方法及其应用

王夙博 方莲花 杜冠华

中国药学杂志 ›› 2012, Vol. 47 ›› Issue (2) : 81-84.

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PDF(941 KB)
中国药学杂志 ›› 2012, Vol. 47 ›› Issue (2) : 81-84.
综述

血管内皮细胞与平滑肌细胞体外共培养方法及其应用

  • 王夙博,方莲花*,杜冠华*
作者信息 +
文章历史 +

摘要

目的 介绍血管内皮细胞(endothelial cells,ECs)和血管平滑肌细胞(smooth muscle cells,SMCs)体外共培养方法及其应用,为研究心血管疾病的发病机制和新药开发提供方法学支持。方法 查阅国内外有关文献,总结、归纳已报道的ECs/SMCs共培养模型及其相关应用。结果与结论 笔者综述了不同ECs/SMCs共培养模型的特点,并总结了体外共培养模型在细胞信号传导、动脉粥样硬化发病机制、心血管生物力学和组织工程学等研究中的应用。

关键词

内皮细胞 / 平滑肌细胞 / 共培养 / 切应力 / 动脉粥样硬化

引用本文

导出引用
王夙博 方莲花 杜冠华. 血管内皮细胞与平滑肌细胞体外共培养方法及其应用[J]. 中国药学杂志, 2012, 47(2): 81-84

参考文献


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基金

重大新药创制科技重大专项(2009ZX09302-003,2009ZX09501-021);科技部科技基础性工作专项重点项目(2007FY130100);卫生部公益性行业科研专项(200902008)
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