目的 建立一种测定降压类中成药及保健品中添加30种化学药的超高效液相-串联四级杆质谱方法。方法 多反应监测模式测定，以Waters ACQUITY UPLC BEH C₁₈柱进行分离，甲醇-0.1%甲酸溶液梯度洗脱，流速：0.2 mL·min^-1。离子化模式：ESI⁺。结果 30种化学药测定的线性范围分别在10～1 000.0， 0～400.0， 2.0～400.0 μg·L^-1，r分别在0.990 3～0.999 8之间，检出浓度分别在0.01~0.83 μg·L^-1之间， 3个水平的回收率分别在72.2%～123.4%之间。结论 该方法快速、准确、灵敏，可用于降压类中成药及保健品中添加30种化学药的测定。

OBJECTIVE To establish a method for determination of 30 antihypertensive medicines adulterated in traditional Chinese patent medicines and health foods by UPLC triple-quadrupole tandem mass spectrometer. METHODS Multi-reactions monitoring (MRM) technology was used. The separation was performed on a Waters ACQUITY UPLC^TM BEH C₁₈ column with a gradient mobile phase of methanol - 0.1% formic acid at flow rate of 0.2 mL·min^-1. The ionization mode was ESI⁺. RESULTS The standard curves of the 30 chemical medicines showed good linearity over the concentration ranges of 10-1 000.0 ， 0-400.0 and 2.0-400.0 μg·L^-1 (r=0.990 3-0.999 8). The detection limits of the 30 chemical medicines were between 0.01-0.83 μg·L^-1 and the average recoveries were 72.2%-123.4% at 3 levels. CONCLUSION The method is rapid and sensitive， and suitable for the determination of 30 chemical medicines in traditional Chinese patent medicines and health foods.