乌骨藤总苷H的化学成分研究

沈利君 周建设 李晓誉 陈金文

中国药学杂志 ›› 2011, Vol. 46 ›› Issue (8) : 585-588.

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中国药学杂志 ›› 2011, Vol. 46 ›› Issue (8) : 585-588.
论著

乌骨藤总苷H的化学成分研究

  • 沈利君1,周建设1,李晓誉2, 陈金文1
作者信息 +

Study on the Chemical Constituents of Total Glycoside H of Marsdenia tenacissima

  • SHEN Li-jun1,ZHOU Jian-she1,LI Xiao-yu2,CHEN Jin-wen1
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摘要

目的 研究乌骨藤总苷H的化学成分。方法 采用柱色谱和HPLC技术对乌骨藤总苷H中的化学成分进行分离纯化,并通过理化性质和波谱方法鉴定其结构。结果 从骨藤总苷H中分离得到6个化合物,分别鉴定为tenacissoside A(1、tenacissoside B(2、tenacissoside C(3、tenacissoside D(4、marsdenoside K(5、11-α-O-乙酰基-12-β-O-惕各酰基tenacigenin B 3-O-β-D-葡萄吡喃糖基-(1→4-6-去氧-3-O-甲基-β-D-阿洛吡喃糖基-(1→4-β-D-夹竹桃吡喃糖苷(6。结论 化合物6是新化合物,为首次从该属植物中分离得到。

Abstract

OBJECTIVE To investigate the chemical constituents of the total glycoside H of Marsdenia tenacissima. METHODS The compounds were isolated and purified by column chromatography and HPLC. Their structures were identified by the physicochemical characteristics and spectroscopic analyses. RESULTS Six compounds were isolated from total glycoside H of Marsdenia tenacissima, and their structures were identified as tenacissoside A(1, tenacissoside B(2, tenacissoside C(3, tenacissoside D(4, marsdenoside K(5, 11-α-O-ethanoyl-12-β-O-tigloxyl tenacigenin B 3-O-β-D-glucopyranosyl-(1→4-6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→4-β-D-oleandropyranoside(6. CONCLUSION Compound 6 was isolated from this plant for the first time.

关键词

乌骨藤 / 11-α-O-乙酰基-12-β-O-惕各酰基tenacigenin B 3-O-β-D-葡萄吡喃糖基-(1→4-6-去氧-3-O-甲基-β-D-阿洛吡喃糖基-(1→4-β-D-夹竹桃吡喃糖苷 / 化学成分

Key words

Marsdenia tenacissima / 11-α-O-ethanoyl-12-β-O-tigloxyl tenacigenin B 3-O-β-D-glucopyranosyl-(1→4-6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→4-β-D-oleandropyranoside / chemical constituents

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导出引用
沈利君 周建设 李晓誉 陈金文. 乌骨藤总苷H的化学成分研究[J]. 中国药学杂志, 2011, 46(8): 585-588
SHEN Li-jun;ZHOU Jin-she;LI Xio-yu;CHEN Jin-wen . Study on the Chemical Constituents of Total Glycoside H of Marsdenia tenacissima[J]. Chinese Pharmaceutical Journal, 2011, 46(8): 585-588

参考文献


[1] SHUJI M, KIMIKO Y, KOJI H, et al. Five glycosides from the Chinese drug “tong-guan-san”: The stems of Marsdenia tenacissima[J]. Phytochemistry, 1986, 25(12: 2861-2865.
[2] DENG J, LIAO Z X, CHENG D F. Three new polyoxypregnane glycosides from Marsdenia tenacissima[J]. Helv Chim Act, 2005(88: 2675-2682.
[3] NAKAGAWA T, HAYASHI K, WADA K, et al. A comparison of 13C-NMR with its diastereomeric isomer, strophanthobiose[J]. Tetrahedron Lett, 1982, 23(51: 5431-5434.
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