沙利度胺构象研究与临床应用进展

谭昀杜熙 杨薇 李玉珍

中国药学杂志 ›› 2011, Vol. 46 ›› Issue (5) : 391-395.

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中国药学杂志 ›› 2011, Vol. 46 ›› Issue (5) : 391-395.
药物与临床

沙利度胺构象研究与临床应用进展

  • 谭昀杜熙,杨薇,李玉珍
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摘要

目的 回顾沙利度胺曲折的发展史,介绍其特殊的代谢与药理作用特点,以及目前在临床上的最新研究热点和治疗地位,提出药物在研发和使用中值得注意的几个方面。方法 查阅国内外文献,分析整理。结果结论 从药物的构象、代谢特点与药理作用、不良反应的关系,结合新兴的药物基因组学、分子生物学研究方法全面深入的研究,可能对活性药物作出更加准确公平的判断。

关键词

沙利度胺 / 异构体 / 药理作用 / 不良反应 / 临床应用

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谭昀杜熙 杨薇 李玉珍. 沙利度胺构象研究与临床应用进展[J]. 中国药学杂志, 2011, 46(5): 391-395

参考文献


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