Effect of Purple Sweet Potato Flavonids on Blood Glucose and Oxidative Stress in Diabetic Rats
JIANG Hui-fang1， LI Xiang-rong2*， CHEN Xiao-le2， SHAO Ying-ying1
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收稿日期
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出版日期
2011-11-11
2011-11-11
2011-10-15
发布日期
2011-10-15
摘要
目的 研究紫心甘薯总黄酮（PSPF）的降糖及其抗氧化作用。方法 采用链脲佐菌素（STZ，65 mg·kg-1）腹腔注射诱导形成糖尿病大鼠模型，实验组大鼠分为正常对照组、糖尿病模型组、PSPF高剂量组（240 mg·kg-1），中剂量组（120 mg·kg-1），低剂量组（60 mg·kg-1），阳性对照组(二甲双胍，90 mg·kg-1)，PSPF灌胃4周，每天测量体重、饮食和饮水量，初期、中期、后期测量空腹血糖（FBG），最后取血测定糖化血清蛋白（GSP）、丙二醛（MDA）、还原型谷胱甘肽（GSH）、超氧化物歧化酶（T-SOD）的变化并测量餐后2 h血糖（2 h BG）。结果 PSPF灌胃4周后，糖尿病大鼠“三多一少”症状明显改善，与模型组相比，高、中灌胃组均有效降低FBG、GSP、2 h BG、MDA，提高大鼠血清中的T-SOD、GSH含量（P<0.01）；低剂量灌胃组均可明显改善FBG、GSP（P<0.05）、MDA、T-SOD含量（P<0.01）；血糖与抗氧化指标统计学分析相关性显著（P<0.05）。结论 PSPF可以明显改善糖尿病大鼠的血糖异常，提高大鼠抗氧化能力。
Abstract
OBJECTIVE To study hypoglycemic and antioxidant effects of purple sweet potato flavonoids (PSPF). METHODS Diabetes mellitus (DM) was induced in rats by intraperitoneal injection of streptozotocin (STZ， 65 mg·kg-1). All the rats were divided into six groups randomly， including normal control group， diabetic model group， metformin group(90 mg·kg-1)， PSPF high-dose (240 mg·kg-1)， medium dose (120 mg·kg-1) and low dose group (60 mg·kg-1)， weight，food and fluid intake were monitored every day ， fasting blood glucose （FBG）was measured every 2 week and at the end of the experiment， GSP， MDA， GSH， T-SOD changes were tested. Also， blood glucose 2 h after meal（2 h BG）was measured . RESULTS Compared with diabetic model group， diabetic symptoms were ameliorated after rats were fed with PSPF. The levels of blood glucose， GSP， 2 h BG， MDA were decreased and serum T-SOD， GSH were increased remarkably in the groups of PSPF 120 and 240 mg·kg-1（P<0.01）； the levels of blood glucose， serum GSP（P<0.05）， MDA， T-SOD（P<0.01） were improved in the group of PSPF 60 mg·kg-1.CONCLUSION Purple sweet potato flavonoids can decrease the blood glucose level and increase antioxidant capacity of diabetic rats.
JING Hui-fng;LI Xing-rong;CHEN Xio-le;SHO Ying-ying.
Effect of Purple Sweet Potato Flavonids on Blood Glucose and Oxidative Stress in Diabetic Rats[J]. Chinese Pharmaceutical Journal, 2011, 46(20): 1570-1573
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参考文献
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