目的 研究盐酸多沙普仑注射液在维吾尔族和汉族健康人体内的药动学。方法 选择维吾尔族和汉族健康受试者各10人，单次静脉滴注盐酸多沙普仑注射液50 mg。用高效液相色谱法测定血浆中多沙普仑的浓度。用DAS2.0药动学程序进行房室模型判断并计算药动学参数。结果 静脉滴注盐酸多沙普仑后的体内过程符合二室模型，维吾尔族和汉族受试者的主要药动学参数，t_1/2α分别为(0.49±0.42)和(0.33±0.24) h，t_1/2β分别为(3.65±2.07)和(3.87±2.17) h，V_c分别为(0.788±0.523)和(0.354±0.197) L·kg-1，V_d分别为(1.812±0.986)和(1.350±0.957) L·kg-1，CL分别为(0.394±0.251)和(0.245±0.113) L·h-1·kg-1，AUC_0-12分别为(2.320±0.700)和(3.513±1.260) mg·h·L-1，AUC_0-∞分别为(2.682±0.801)和(4.061±1.445) mg·h·L-1。结论 维吾尔族和汉族健康受试者单次静脉滴注盐酸多沙普仑后V_c、AUC_0-12和AUC_0-∞的差异有统计学意义。

OBJECTIVE To study the pharmacokinetics of doxapram injection in Uigur and Han healthy volunteers. METHODS Ten Uigur and 10 Han healthy volunteers were given a single dose of 50 mg doxapram injection intravenously. The plasma concentrations of doxapram were determined by HPLC. The pharmacokinetic parameters were calculated with DAS2.0 software. RESULTS The plasma concentration-time curves of doxapram were fitted to a two-compartment model. The main pharmacokinetic parameters in Uigur and Han healthy volunteers were as follows： t_1/2α (0.49±0.42) and (0.33±0.24)h， t_1/2β (3.65±2.07) and (3.87±2.17) h， V_c (0.788±0.523) and (0.354±0.197)L·kg-1， V_d(1.812±0.986) and (1.350±0.957) L·kg-1， CL (0.394±0.251) and (0.245±0.113)L·h-1·kg-1， AUC_0-12 (2.320±0.700) and (3.513±1.260)mg·h·L-1， AUC_0-∞ (2.682±0.801) and (4.061±1.445) mg·h·L-1， respectively. CONCLUSION There is significant difference in the pharmacokinetic parameters V_c， AUC_0-12， AUC_0-∞ between Uigur and Han healthy volunteers.