目的 制备并评价芦丁-羟丙基-β-环糊精包合物。方法 本实验采用冷冻干燥法制备芦丁- 羟丙基 -β- 环糊精包合物，通过L₉（3）4正交设计优选投料比、包合时间、包合温度，通过考察包合物的溶解度、相溶解度验证包合物的形成，使用X射线衍射法对包合物进行鉴定。结果 正交设计筛选出的最佳条件为投料比1∶4，包合时间2 h，包合温度为45 ℃。以该法制备的芦丁-羟丙基-β-环糊精包合物溶解度得到显著提高，达到9.61 mg·mL-1。结论 本实验采用的包合方法及材料可以显著改善芦丁的溶解性能。

OBJECTIVE To prepare and characterize the rutin-HP-β-CD inclusion complexes. METHODS Rutin-HP-β-CD inclusion complexes were prepared by the lyopyilization. The reaction conditions like materials ratio， reaction time and temperature were selected by L₉（3）4 orthogonal experiment. According to the RESULTS of solubility and phase solubility test and X-Ray diffraction pattern， the success of inclusion between rutin and HP-β-CD were identified. RESULTS The best ratio of Rutin and HP-β-CD was 1∶4， the temperature was 45 ℃， and the reaction time was 2 h. The solubility of inclusion complexes prepared under the conditions was about 9.61 mg·mL-1， which increased obviously than pure rutin. CONCLUSION The preparation of rutin-HP-β-CD inclusion complexes could increase the solubility obviously.