糖尿病心肌病与肾素-血管紧张素系统及其干预药物

张一弛 牟艳玲 解砚英

中国药学杂志 ›› 2011, Vol. 46 ›› Issue (16) : 1217-1219.

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中国药学杂志 ›› 2011, Vol. 46 ›› Issue (16) : 1217-1219.
综述

糖尿病心肌病与肾素-血管紧张素系统及其干预药物

  • 张一弛,牟艳玲,解砚英*
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摘要

目的 综述糖尿病心肌病(diabetic cardiomyopathy,DCM)与肾素-血管紧张素系统(renin-angiotensin system,RAS)的关系及其药物治疗进展。方法 依据近年来国内外相关文献报道,进行归纳分析和分类总结。结果结论 糖尿病时RAS被激活,升高的血管紧张素Ⅱ(angiotension Ⅱ,AngⅡ)通过细胞表面的AT1受体,刺激心肌成纤维细胞增生及胶原代谢改变,引起心脏结构重塑,导致心肌间质及血管周围纤维化,心室肌僵硬而影响舒张功能,出现DCM的临床症状。RAS的主要成分Ang Ⅱ、Ang-(1-7)、Ac-SDKP和血管紧张素受体(angiotension receptor,ATR)在糖尿病心肌病的发生发展过程中起重要作用,血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)及血管紧张素Ⅱ受体阻断剂(angiotension Ⅱreceptor blocker,ARB)则对DCM具有一定防治效应。

关键词

糖尿病心肌病 / 肾素-血管紧张素系统 / 血管紧张素转换酶抑制剂 / 血管紧张素Ⅱ受体拮抗剂

引用本文

导出引用
张一弛 牟艳玲 解砚英. 糖尿病心肌病与肾素-血管紧张素系统及其干预药物[J]. 中国药学杂志, 2011, 46(16): 1217-1219

参考文献


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