二氢嘧啶脱氢酶活性从基础研究走向临床应用的研究进展

杜小莉 朱珠 曹运莉

中国药学杂志 ›› 2011, Vol. 46 ›› Issue (15) : 1142-1145.

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PDF(539 KB)
中国药学杂志 ›› 2011, Vol. 46 ›› Issue (15) : 1142-1145.
综述

二氢嘧啶脱氢酶活性从基础研究走向临床应用的研究进展

  • 杜小莉,朱珠*,曹运莉
作者信息 +
文章历史 +

摘要

目的 二氢嘧啶脱氢酶(DPD)缺乏与氟化嘧啶类药物严重不良反应之间的相关性已为大量研究所证实。DPD测定作为临床常规检测项目的必要性受到关注,笔者概述该领域研究的进展及趋势,为我国开展相关研究提供借鉴。方法 检索欧美各国药政部门官方网站、PubMed及CNKI数据库,对相关规定和文献进行分析总结。结果 欧美各国药政部门已将DPD缺乏列入氟化嘧啶类药物的说明书。初步的前瞻性研究显示,用药前测定DPD活性可显著降低不良反应发生率及处置不良反应所产生的额外费用。目前尚待解决的关键问题是选择何种测定方法及相应临界值的确定。结论 DPD检测有可能在未来成为临床常规检测项目。我国有必要借鉴其他国家有关规定以及国际研究趋势,在该领域开展深入研究,为促进氟化嘧啶类药物在我国患者的安全应用提供更多信息。

关键词

二氢嘧啶脱氢酶 / 缺乏 / 氟化嘧啶类药物

引用本文

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杜小莉 朱珠 曹运莉. 二氢嘧啶脱氢酶活性从基础研究走向临床应用的研究进展[J]. 中国药学杂志, 2011, 46(15): 1142-1145

参考文献


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