摘要
目的 测定愈创木酚磺酸钾中异构体的含量。方法 采用NMR法测定愈创木酚磺酸钾异构体结构中5-H的积分面积，按相对定量模式计算异构体的含量，并与HPLC加校正因子计算测定结果进行比较。结果 采用NMR法测定3批愈创木酚磺酸钾中3-羟基-4-甲氧基苯磺酸钾和4-羟基-3-甲氧基苯磺酸钾的含量，与HPLC测定结果基本一致。结论 NMR法测定结果准确，方法简单快速。
Abstract
OBJECTIVE To determine the content of potassium guaiacolsulfonate isomer. METHODS The content of 3-hydroxy-4-methoxybenzenesulfonic acid monopotassium and 4-hydroxy-3-methoxybenzenesulfonate monopotassium in potassium guaiacolsulfonate were determined by NMR. The quantitative analysis results were compared with those obtained by HPLC-method correct factor. RESULTS The contents of 3-hydroxy-4- methoxybenzenesulfonic acid monopotassium and 4-hydroxy-3- methoxybenzenesulfonic acid monopotassium in three batches of samples determined by NMR were identical with the results by HPLC. CONCLUSION The NMR method is fast， simple and accurate.
关键词
愈创木酚磺酸钾 /
核磁共振 /
含量测定
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Key words
potassium guaiacolsulfonate /
nuclear magnetic resonance /
quantitative analysis
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魏宁漪 周颖 胡昌勤.
愈创木酚磺酸钾异构体的NMR定量分析[J]. 中国药学杂志, 2011, 46(12): 953-954
WEI Ning-yi;ZHOU Ying;HU Chng-qin.
Determination of Potassium Guaiacolsulfonate Isomer by NMR[J]. Chinese Pharmaceutical Journal, 2011, 46(12): 953-954
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参考文献
[1] J.P XV [S]. 2007： 1011-1012.
[2] Drug Specifications Promulgated by State Food and Drug Administration(国家药品标准转正标准 [S]. Vol. 5： 270-272.
[3] Drug Specifications Promulgated by State Food and Drug Administration(国家药品标准转正标准 [S]. Vol. 36： 204-205.
[4] DING M H. Determination of potassium guaiacolsulfonate in compound paracetamol and methlephedrine oral solution by HPLC [J]. Strait Pharm J(海峡杂志， 2006， 118(4： 85-87.
[5] WANG Q， WANG M T， ZHANG Z Q. Quantitative determination of tilmicosin by 1H-NMR[J]. J Instr Anal(分析测试学报， 2003， 22(6： 101-103.
[6] Ch. P (2010 Vol Ⅱ (中国药典2010年版. 二部 [S]. 2010： Appendix 81-83.
[7] ZHANG Y F， ZENG Y L，XING J， et al. Determination of the isomeric ingredients in potassium guaiacolsulfonate[J]. Chin J Pharm Anal (药物分析杂志，2003，23（5：338-341.
[8] WANG Y， HAO S L， YANG H X， et al. Standardization of the national reference standard of the impurity of glutathione [J]. Chin Pharm Aff (中国药事，2010，24（3：248-249.
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脚注
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