目的 探讨半合成高脂饲料和合成高脂饲料对Wistar大鼠糖脂代谢的影响。方法 雄性Wistar大鼠随机分为3组，正常对照组（Con，n=7给予普通饲料；高脂1组（HF1，n=7给予合成高脂饲料；高脂2组（HF2，n=7给予半合成高脂饲料。观察大鼠体重变化、能量摄入、血清总甘油三酯、血清总胆固醇水平，进行胰岛素耐量实验和口服葡萄糖耐量实验。结果 与正常对照组大鼠相比，半合成高脂饲料和合成高脂饲料喂养的大鼠第1周出现体重显著性升高；第2周出现血清总甘油三酯水平显著性升高；第4周出现明显的糖耐量异常和胰岛素抵抗。结论 半合成高脂饲料和合成高脂饲料喂养的大鼠均可较好地模拟糖脂代谢异常的主要生理病理状态，具有肥胖、口服葡萄糖糖耐量异常、胰岛素抵抗、高甘油三酯血症等基本特征，并且半合成高脂饲料更适于诱导大鼠糖脂代谢异常。

OBJECTIVE To investigate the influence of semi-synthetic high fat diet and synthetic high fat diet on glucose and lipid metabolism in Wistar rats. METHODS Male Wistar rats were randomly divided into 3 groups： control group (Con， n=7 fed with standard chow diet， high fat group 1 (HF1， n=7 fed with synthetic high fat diet， and high fat group 2 (HF2， n=7 fed with semi-synthetic high fat diet. Body weight， energy intake， and fasted serum lipid level (total triglyceride， TG and total cholesterol， TC of the rats were monitored. Oral glucose tolerance test (OGTT and insulin tolerance test (ITT were performed. RESULTS Weight gain in the first week， hyperlipidemia in the second week， and impaired glucose tolerance and insulin resistance in the fourth week were observed in the rats fed with semi-synthetic high fat diet or synthetic high fat diet compared with control group. CONCLUSION The rats fed with semi-synthetic high fat diet or synthetic high fat diet have the characteristics of abnormal glucose and lipid metabolism， such as obesity， impaired glucose tolerance， insulin resistance and hyperlipidemia. Semi-synthetic high fat diet is superior in inducing abnormal glucose and lipid metabolism.