摘要
目的 研究中药翻白草(Potentilla discolor Bunge. 中的化学成分。方法 采用各种色谱技术分离纯化化合物，并通过理化性质和波谱学方法 鉴定化合物的结构。结果 从翻白草中分离鉴定了11个多酚类化合物，其中黄酮苷元4个：分别为芹菜素(1，木犀草素(2，山柰酚(3，槲皮素(4；黄酮苷3个：分别为槲皮苷(5，刺蒺藜苷(6，山柰酚-3-O-β-D-葡萄糖醛酸苷(7；鞣花酸及衍生物3个：分别为鞣花酸(8，鞣花酸-3-甲醚(9，鞣花酸-3-甲醚-4′-O-α-L-吡喃鼠李糖苷(10 以及有机酸类1个：没食子酸(11。结论 化合物2，3和9为首次从翻白草中分离得到，化合物9为首次从委陵菜属植物中分离得到。
Abstract
OBJECTIVE To study the polyphenols of Potentilla discolor Bunge. METHODS The crude drug of Potentilla discolor was extracted with 95% ethanol and purified by repeated chromatographic methods. The structures of the isolated compounds were elucidated by physicochemical and spectral analysis. RESULTS Eleven compounds were yielded and identified as： kaempferol(1，apigenin(2，luteolin(3，quercetin(4，quercetrin(5，tribuloside(6，kaempferol-3-O-β-D-glucuronide(7，ellagic acid(8，ellagic acid-3-O-methyl ether(9，ellagic acid-3-O-methyl ether-4-O-α-L-rhamnopyranoside(10 and gallic acid(11. CONCLUSION Compound 2，3 and 9 were obtained from Potentilla discolor Bunge for the first time，and compound 9 was yielded from the genus of Potentilla for the first time.
关键词
委陵菜属 /
翻白草 /
多酚类 /
黄酮类 /
鞣花酸类
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Key words
Potentilla /
Potentilla discolor Bunge /
polyphenols /
flavonoids /
ellagic acid derivatives
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张巍巍 张鹏 程伟 王邠 王京丽 张庆英 梁鸿 赵玉英.
翻白草中多酚类化学成分研究[J]. 中国药学杂志, 2011, 46(1): 20-23
ZHNG Wei-wei;ZHNG Peng;CHENG Wei;WNG in;WNG Jing-li;ZHNG Qing-ying;LING Hong;ZHO Yu-ying.
Polyphenols from Potentilla discolor Bunge.[J]. Chinese Pharmaceutical Journal, 2011, 46(1): 20-23
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参考文献
［1］ MICHA T，KLAUS P. Potentilla——A review of its phytochemical and pharmacological profile [J]. J Ethnopharmacol，2009，122（2：184-204.
［2］ Drug Administration of Shandong Province. Shandong Chinese Materia Medica Standards(山东省中药材标准 [S]. 2002：283-284.
［3］ Editorial Committee of Flora of China. Flora of China(中国植物志 [M]. Vol 52，Sect 2. Beijing： Science Press，1983： 291.
［4］ HARBONE J B，MABRY T J. The Flavonoids： Advances in Research[M]. London and Newyork： Chapman and Hall Ltd，1982： 60，72，83，91，93.
［5］ ZHONG H J，CHEN J J，WANG H Y，et al. Chemical investigation on Potentilla griffithii var. velutina [J]. Chin Tradit Herbal Drugs(中草药，2000，31(7： 488-490.
［6］ QIAO C F，HAO X J，XU L S，et al. Studies on chemical constituents of Alpinia jianganfeng [J]. China J Chin Mater Med(中国中药杂志，2002，27(2： 130-131.
［7］ WANG Y Q，SI J Y，LIU X M，et al. Isolation，identification and quantitative determination of ellagic acid and brevifolincarboxylic acid in Duchesnea indica by RP-HPLC [J]. Nat Prod Res Dev(天然产物研究与开发，2008，20（2： 667-671.
［8］ NAISHENG B，KANGHE，MARC R，et al. Active compounds from Lagerstroemia speciosa，insulin-like glucose uptake-stimulatory/inhibitory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells [J]. J Agric Food Chem，2008，56(24： 11668-11674.
［9］ XUE P F，ZHAO Y Y，WANG B，et al. Secondary metabolites from Potentilla discolor Bunge(Rosaceae [J]. Biochem Syst Ecol，2006，34（3： 825-828.
［10］ LU Y R，FOOL Y. The polyphenol constituents of grape pomace [J]. Food Chem，1999，65（1： 1-8.
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脚注
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