RP-HPLC研究冰片对广枣中没食子酸在家兔体内的药动学影响

桑柏 王世祥 兰薇 于洁 申旭霁 梁杨静 郑晓晖

中国药学杂志 ›› 2010, Vol. 45 ›› Issue (7) : 548-550.

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中国药学杂志 ›› 2010, Vol. 45 ›› Issue (7) : 548-550.
论著

RP-HPLC研究冰片对广枣中没食子酸在家兔体内的药动学影响

  • 桑柏,王世祥,兰薇,于洁,申旭霁,梁杨静,郑晓晖
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Effects of Borneol on the Pharmacokinetics of Galic Acid in Herb of Guangzao in Rats by RP-HPLC

  • SANG Bo, WANG Shi-xiang, LAN Wei, YU Jie, SHEN Xu-ji, LIANG Yang-jing, ZHENG Xiao-hui
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摘要

目的 研究冰片对广枣中没食子酸药动学的影响。方法 采用RP-HPLC测定广枣水提液和广枣-冰片配伍液灌胃后家兔血浆中没食子酸的药-时曲线,DAS2.0药动学软件拟合房室模型,计算药动学参数,比较没食子酸在家兔体内的药动学差异。结果 广枣单独给药、广枣-冰片配伍后给药,没食子酸在体内代谢动力学模型均为二室开放模型。配伍后,没食子酸的达峰时间提前,V/F减少,CL/F增大。结论 冰片可以促进没食子酸的转运和吸收,体现的了冰片对广枣的增效作用。

Abstract

OBJECTIVE To observe the effect of borneol on the pharmacokinetics of galic acid in rats. METHODS The concentrations of galic acid in plasma were determined by HPLC after administrating the extraction of Guangzao or Guangzao combined with borneol in rats by ig injection. The data were processed by DAS2.0 software to calculate the pharmacokinetic parameters and then to find the differences between two groups. RESULTS Both groups received Guangzao and Guangzao combined with borneol. The pharmacokinetics model of galic acid followed the two-compartment model. After combining with borneol, the peaking time and V/F of gallic acid were decreased, meanwhile, the CL/F of galic acid were increased. CONCLUSION Borneol can accelerate the transportation and absorption of gallic acid in rats. It may imply that the borneol can increase the therapeutic efficacy of Guangzao.

关键词

广枣 / 没食子酸 / 冰片 / 药动学

Key words

Guangzao (Choerospondias axillaries Burttet Hill) / galic acid / borneol / pharmacokinetics

引用本文

导出引用
桑柏 王世祥 兰薇 于洁 申旭霁 梁杨静 郑晓晖. RP-HPLC研究冰片对广枣中没食子酸在家兔体内的药动学影响[J]. 中国药学杂志, 2010, 45(7): 548-550
SNG o;WNG Shi-xing;LN Wei;YU Jie;SHEN Xu-ji;LING Yng-jing;ZHENG Xio-hui. Effects of Borneol on the Pharmacokinetics of Galic Acid in Herb of Guangzao in Rats by RP-HPLC[J]. Chinese Pharmaceutical Journal, 2010, 45(7): 548-550

参考文献


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