明胶壳聚糖西咪替丁缓释微囊的制备和体外释放度研究

曲俊兵 刘晟

中国药学杂志 ›› 2010, Vol. 45 ›› Issue (7) : 531-533.

PDF(639 KB)
中国药学杂志
PDF(639 KB)
中国药学杂志 ›› 2010, Vol. 45 ›› Issue (7) : 531-533.
论著

明胶壳聚糖西咪替丁缓释微囊的制备和体外释放度研究

  • 曲俊兵1,刘晟2
作者信息 +

Preparation of Gelatin Microcapsules of Chitosan Sustained-Release and Its in Vitro Release Study

  • QU Jun-bing1 ,LIU Sheng2
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摘要

目的 将明胶与壳聚糖用作微胶囊的壁材，制备西咪替丁缓释微囊。 方法 以明胶用量（A）、壳聚糖用量（B）、戊二醛用量（C）等三因素三水平进行L9（34）正交实验，从累积释放度方面考察，优选最佳工艺配方。结果 对微囊释放度影响作用较大的因素顺序是B＞A＞C，选出最佳处方工艺为A2B3C1。结论 以明胶与壳聚糖制备的含西咪替丁药物微囊具有良好的缓释作用。

Abstract

OBJECTIVE To prepare the sustained-released microcapsules containing cimetidine with gelatin and chitosan as the basic material for the coating of microcapsules. METHODS According to the L9(34) orthogonal design, the amount of gelatin(A), chitosan(B), glutaraldehyde(C) formulas were optimized. RESULTS The factors of B, A and C showed a great effect on release rate, and the optimum formula was A2B3C1. CONCLUSION The cimetidine microcapsules with gelatin and chitosan showed good characters of relaxation.

关键词

西咪替丁 / 壳聚糖 / 明胶 / 缓释微囊

Key words

KEY WORDS: cimetidine / chitosan / gelatin / sustained-release microcapsules

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曲俊兵 刘晟. 明胶壳聚糖西咪替丁缓释微囊的制备和体外释放度研究[J]. 中国药学杂志, 2010, 45(7): 531-533
QU Jun-ing;LIU Sheng. Preparation of Gelatin Microcapsules of Chitosan Sustained-Release and Its in Vitro Release Study[J]. Chinese Pharmaceutical Journal, 2010, 45(7): 531-533

参考文献


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