摘要
目的 对柳珊瑚Verrucella sp.的化学成分进行分离与结构鉴定。方法 采用反复硅胶柱色谱法及重结晶技术进行分离和纯化，根据理化性质及现代波谱技术确定化合物的结构。结果 从柳珊瑚Verrucella sp. 的乙酸乙酯提取物中分离鉴定了7个化合物，其结构分别确定为：junceellin (1)，praelolide (2)，胆甾醇(cholesterol，3)，(E)-N-2(1，3-二羟基-4-十八烯基)-十六酰胺\[ (E)-N-2-(1，3-dihydroxy octadecan-4-en)-hexadecamide，4\]，胸腺嘧啶(thymine，5)，胸腺嘧啶脱氧核苷(thymidine，6)，鲨甘醇(batyl alcohol，7)。结论 化合物1～7均为首次从该珊瑚中分离得到。
Abstract
OBJECTIVE To isolate and identify the chemical constituents in gorgonian Verrucella sp.METHODS Chromatography and recrystallization were performed for the isolation and purification， the structures were determined by extensive spectroscopic analysis in association with physical and chemical properties. RESULTS Seven compounds were isolated from the CH3COOCH2CH3 extracts of gorgonian Verrucella sp.， their structures were identified as junceellin(1)， praelolide (2)， cholesterol(3)， (E)-N-2-(1，3-dihydroxy octadecan-4-en)-hexadecamide(4)， thymine(5)， thymidine(6) and batyl alcohol(7). CONCLUSION All the compounds were isolated from the gorgonian for the first time.
关键词
柳珊瑚 /
Verrucella sp. /
化学成分
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Key words
gorgonian /
Verrucella sp. /
chemical constituents
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王玮 徐石海 廖小建.
柳珊瑚Verrucella sp. 中几种化学成分的分离与结构鉴定[J]. 中国药学杂志, 2010, 45(3): 172-174
WNG Wei;XU Shi-hi;LIO Xio-jin.
Isolation and Structure Identification of Several Chemical Constituents in Gorgonian Verrucella sp.[J]. Chinese Pharmaceutical Journal, 2010, 45(3): 172-174
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参考文献
［1］ LIAW C C， SHEN Y C， LIN Y S， et al. Frajunolides E-K， briarane diterpenes from Junceella fragilis［J］. J Nat Prod， 2008， 9(71)：1551-1556.
［2］ PAN Y C， ZENG L M. Extraction and separation of antitumor substances in marine corals ［J］. J Instr Anal(分析测试学报) ， 2006， 1(25)：133-138.
［3］ SUBRAHMANYAM C， KULATHEESWARAN R， WARD R S. Briarane diterpenes from the Indian ocean gorgonian Gorgonella umbraculum［J］. J Nat Prod， 1998， 9(61)：1120-1122.
［4］ LUO Y K， LONG K H， FANG Z. Studies on the chemical constituents of the Chinese gorgonia (Ⅲ)： Isolation and identification of a new polyacetoxy Chlorine-containing diterpene lactone (praelolide) ［J］. Acta Sci Nat Univ Sunyatseni(中山大学学报：自然科学版) ， 1983，22(1)： 83-92.
［5］ YANG J， QI S H， ZHANG S， et al. Chemical constituents from the south China sea gorgonian coral Subergorgia reticulata［J］．J Chin Med Mater(中药材) ， 2006， 29(6)：555-557.
［6］ LI R S， LIU Q. Studies on the chemical constituents of the Chinese soft coral (Ⅲ Ⅹ Ⅵ) structures of two ceramides ［J］. Chin J Mar Drugs(中国海洋药物)， 1996，15(3)：10-13.
［7］ LIAO X J， XU S H， HUANG Q C， et al. Studies on chemical constituents from Callyspongia fibrosa(Ⅰ) ［J］. Chin J Spectrosc Lab (光谱实验室)， 2005， 22(2)：281-283.
［8］ SONG F H， FAN X， XU X L， et al. Studies on the chemical constituents of the marine sponge Tedania sp.［J］. Chin J Mar Drugs (中国海洋药物)， 2004，23(3)：11-14.
［9］ HE X X， SU J Y， ZEN L M， et al. Studied on chemical constitution of Sinularia simpsoni Tix-Dur.［J］. Nat Prod Res Dev(天然产物研究与开发)， 2001，13(2)：14-15.
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