Triterpenoid Saponins from the Leaves of Ilex latifolia
FAN Chun-lin1,2,FAN Long1,2,ZHANG Xiao-qi1,2,WANG Ying1,2,ZHANG Jun-qing3,YE Wen-cai1,2*
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1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China; 2. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; 3. Hainan Medical College, Hainan Provincial Key Laboratory of R&D of Tropical Herbs, Haikou 571101, China
OBJECTIVE To investigate the triterpenoid saponins of the leaves of Ilex latifolia. METHODS The chemical constituents of the water extract of Ilex latifolia were isolated by column chromatography on silica gel, Sephadex LH-20 and ODS columns, respectively. Their structures were elucidated on the basis of physicochemical properties and spectral data. RESULTS Eleven compounds were isolated and their structures were identified as kudinoside D (Ⅰ), kudinoside E (Ⅱ), kudinoside O (Ⅲ), kudinoside N (Ⅳ), kudinoside A (Ⅴ), kudinoside C (Ⅵ), dudinoside F (Ⅶ), latifoloside Q (Ⅷ), latifoloside H (Ⅸ), latifoloside G (Ⅹ) and ilekudinoside G (Ⅺ). CONCLUSION Compounds Ⅰ-Ⅳ, Ⅵ, Ⅶ and Ⅺ were isolated from this plant for the first time.
FN Chun-lin;FN Long;ZHNG Xio-qi;WNG Ying;ZHNG Jun-qing;YE Wen-ci;.
Triterpenoid Saponins from the Leaves of Ilex latifolia[J]. Chinese Pharmaceutical Journal, 2010, 45(16): 1228-1232
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