大叶冬青的三萜皂苷类成分研究

范春林 范龙 张晓琦 王英 张俊清 叶文才

中国药学杂志 ›› 2010, Vol. 45 ›› Issue (16) : 1228-1232.

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中国药学杂志 ›› 2010, Vol. 45 ›› Issue (16) : 1228-1232.
论 著

大叶冬青的三萜皂苷类成分研究

  • 范春林1,2,范龙1,2,张晓琦1,2,王英1,2,张俊清3,叶文才1,2*
作者信息 +

Triterpenoid Saponins from the Leaves of Ilex latifolia

  • FAN Chun-lin1,2,FAN Long1,2,ZHANG Xiao-qi1,2,WANG Ying1,2,ZHANG Jun-qing3,YE Wen-cai1,2*
Author information +
文章历史 +

摘要

目的 对中药苦丁茶主要品种大叶冬青叶的三萜皂苷类成分进行研究。方法 采用硅胶、葡聚糖凝胶LH-20和反相ODS柱色谱分离大叶冬青叶的水提物,通过光谱分析结合理化性质鉴定化合物的结构。结果 从大叶冬青的水提液中分离得到11个化合物,分别鉴定为α-苦丁内酯3-O-β-D-吡喃葡萄糖(1→3)[α-L-吡喃鼠李糖(1→2)]-α-L-吡喃阿拉伯糖苷(Ⅰ)、α-苦丁内酯3-O-β-D吡喃葡萄糖 (1→2)-β-D-吡喃葡萄糖 (1→3)-[α-L-吡喃鼠李糖 (1→2)]-α-L-吡喃阿拉伯糖苷 (Ⅱ)、3-O-β-D-吡喃葡萄糖 (1→2)-β-D-吡喃葡萄糖 (1→3)-[α-L-吡喃鼠李糖 (1→2)]-α-L-吡喃阿拉伯糖斯阿树脂酸28-α-L-吡喃鼠李糖 (1→2)-β-D-吡喃葡萄糖酯苷(Ⅲ)、3-O-β-D-吡喃葡萄糖(1→2)-β-D-吡喃葡萄糖 (1→3)-[α-L-吡喃鼠李糖 (1→2)]-α-L-吡喃阿拉伯糖坡模醇酸28-α-L-吡喃鼠李糖 (1→2)-β-D-吡喃葡萄糖酯苷 (Ⅳ)、β-苦丁内酯3-O-β-D-吡喃葡萄糖 (1→3)-[α-L-吡喃鼠李糖 (1→2)]-α-L-吡喃阿拉伯糖苷(Ⅴ)、β-苦丁内酯3-O-β-D-吡喃葡萄糖 (1→2)-β-D-吡喃葡萄糖 (1→3)-[α-L-吡喃鼠李糖 (1→2)]-α-L-吡喃阿拉伯糖苷(Ⅵ)、γ-苦丁内酯3-O-β-D-吡喃葡萄糖 (1→3)-[α-L-吡喃鼠李糖 (1→2)]-α-L-吡喃阿拉伯糖苷(Ⅶ)、3-O-β-D-吡喃葡萄糖 (1→3)-[α-L-吡喃鼠李糖 (1→2)]-α-L-吡喃阿拉伯糖齐墩果酸28-α-L-吡喃鼠李糖 (1→2)-β-D-吡喃葡萄糖酯苷(Ⅷ)、3-O-β-D-吡喃葡萄糖 (1→3)-[α-L-吡喃鼠李糖 (1→2)]-α-L-吡喃阿拉伯糖斯阿树脂酸28-α-L-吡喃鼠李糖 (1→2)-β-D-吡喃葡萄糖酯苷(Ⅸ)、3-O-β-D-吡喃葡萄糖 (1→3)-[α-L-吡喃鼠李糖-(1→2)]-α-L-吡喃阿拉伯糖坡模醇酸28-α-L-吡喃鼠李糖 (1→2)- β-D-吡喃葡萄糖酯苷(Ⅹ)及δ-苦丁内酯3-O-β-D-吡喃葡萄糖 (1→2)-β-D-吡喃葡萄糖 (1→3)-[α-L-吡喃鼠李糖 (1→2)]-α-L-吡喃阿拉伯糖苷(Ⅺ)。结论 化合物Ⅰ~Ⅳ、Ⅵ、Ⅶ及Ⅺ为首次从该植物中分离得到。

Abstract

OBJECTIVE To investigate the triterpenoid saponins of the leaves of Ilex latifolia. METHODS The chemical constituents of the water extract of Ilex latifolia were isolated by column chromatography on silica gel, Sephadex LH-20 and ODS columns, respectively. Their structures were elucidated on the basis of physicochemical properties and spectral data. RESULTS Eleven compounds were isolated and their structures were identified as kudinoside D (Ⅰ), kudinoside E (Ⅱ), kudinoside O (Ⅲ), kudinoside N (Ⅳ), kudinoside A (Ⅴ), kudinoside C (Ⅵ), dudinoside F (Ⅶ), latifoloside Q (Ⅷ), latifoloside H (Ⅸ), latifoloside G (Ⅹ) and ilekudinoside G (Ⅺ). CONCLUSION Compounds Ⅰ-Ⅳ, Ⅵ, Ⅶ and Ⅺ were isolated from this plant for the first time.

关键词

大叶冬青 / 苦丁茶 / 化学成分 / 三萜皂苷

Key words

Ilex latifolia / kudingcha / chemical constituent / triterpenoid saponin

引用本文

导出引用
范春林 范龙 张晓琦 王英 张俊清 叶文才 . 大叶冬青的三萜皂苷类成分研究[J]. 中国药学杂志, 2010, 45(16): 1228-1232
FN Chun-lin;FN Long;ZHNG Xio-qi;WNG Ying;ZHNG Jun-qing;YE Wen-ci;. Triterpenoid Saponins from the Leaves of Ilex latifolia[J]. Chinese Pharmaceutical Journal, 2010, 45(16): 1228-1232

参考文献


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