靶向血凝素的流感病毒进入抑制剂研究进展

张瑞涛 姜世勃 刘叔文

中国药学杂志 ›› 2010, Vol. 45 ›› Issue (16) : 1208-1212.

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中国药学杂志 ›› 2010, Vol. 45 ›› Issue (16) : 1208-1212.
综 述

靶向血凝素的流感病毒进入抑制剂研究进展

  • 张瑞涛1,姜世勃1, 2,刘叔文1*
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摘要

目的 概述流感病毒包膜蛋白血凝素(Hemagglutinin, HA)的生物学特征,以及以HA为靶点的抗流感病毒进入抑制剂的研究进展。方法 分析、整理和归纳近年来的代表性论文。结果 在流感病毒感染宿主细胞过程中,其包膜糖蛋白HA在病毒的侵入以及与靶细胞的融合过程中起关键的作用。流感病毒与靶细胞结合以及膜融合的过程是药物干预的重要环节。HA由HA1和HA2两个亚基组成,其中HA1亚基与靶细胞膜上的唾液酸受体结合,HA2则为跨膜亚基,介导病毒膜与胞内体膜的融合。流感病毒HA可作为药物的作用靶点,寻找能够抑制流感病毒进入靶细胞的抗流感药物。 作为一种新机制的抗流感药物,流感病毒进入抑制剂可望治疗对现有抗流感药物耐药的流感患者。若与M2离子通道阻断剂、神经氨酸酶抑制剂等抗流感药物联合应用,将有助于提高疗效,降低毒副作用及病毒耐药的发生。结论 流感病毒进入抑制剂作为一种新机制的抗流感药物,将对流感的防治起到突破性的作用。

关键词

流感病毒 / 血凝素 / 抑制剂

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张瑞涛 姜世勃 刘叔文. 靶向血凝素的流感病毒进入抑制剂研究进展[J]. 中国药学杂志, 2010, 45(16): 1208-1212

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