摘要
目的 探讨葡萄籽多酚性成分对小鼠的抗氧化性。方法 小鼠每日颈背皮下注射D-半乳糖溶液(40 mg·kg-1，过滤灭菌)，建立衰老模型；治疗组在注射D-半乳糖的同时以葡萄籽多酚性提取物组不同剂量(10、20、40 mg·kg-1，qd）灌胃；空白组与模型组则以生理盐水代之。结果 葡萄籽多酚性成分能降低血清、脑及肝内丙二醛（MDA）的水平，同时一定程度上能提高超氧化物歧化酶（SOD）及谷胱甘肽过氧物酶（GSH-PX）的活力。结论 葡萄籽多酚性成分具有一定程度的抗氧化作用。
Abstract
OBJECTIVE To investigate the antioxidant effects of polyphenols constituents of grape seed in Mice. METHODS Subacute intoxication induced aging Kunming mice model injected subcutaneously with 40 mg·kg-1·d-1 D-gal were divided into model control group and high，middle，low dosage of polyphenols constituents of grape seed (40，20，10 mg·kg-1·d-1)，while the blank and model group were treated with normal Saline. RESULTS Polyphenols constituents of grape seed improved the activities of SOD and GSH-PX， and obviously increased the levels of MDA in the blood， liver and brain of rats. CONCLUSION Polyphenols constituents of grape seed have the antioxidant efficiency.
关键词
葡萄籽 /
多酚性成分 /
小鼠 /
抗氧化
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Key words
grape seed /
polyphenols constituents /
rats /
antioxidant
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刘向荣 邓银华 刘文 戴迎春.
葡萄籽多酚性成分对小鼠抗氧化作用研究[J]. 中国药学杂志, 2010, 45(11): 835-837
LIU Xing-rong;DENG Yin-hu;LIU Wen;DI Ying-chun .
Antioxidant Effects of Polyphenols Constituents of Grape Seed in Mice[J]. Chinese Pharmaceutical Journal, 2010, 45(11): 835-837
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参考文献
[1] PEKIE B， KOVAC V， ALONSO E. Study of the extraction of proanthocyanidins from grape seeds[J]．Food Chem， 1998， 61(1-2)： 201-206.
[2] MAKOTO S， HIROSHI H， TOSHIAKI A， et al. Antiulcer activity of grape seed extract and procyanidine[J]. Agric Food Chem， 1998， 46（4）： 1460-1464.
[3] TIBOR F， RICARDO S. Catechin and procyanidine composition of seeds from grape cultivars grown in ontario[J]. Agric Food Chem，1997， 45（4）： 1156-1160.
[4] SHU X C， LI Y H， YAN W X， et al. Anti-oxidative effects of proanthocyanidins in mice induced by D-galactose[J].J Hyg Res，2002，31(3)：191-193.
[5] FENG D J， XU G F. Empirical study on anti-oxidative effect of grape seed extracts [J]. Food Drug（食品与药品），2007，9(11)：16-18.
[6] BIANG L， FANG P H. The Chemical components and pharmacological activities of grape seed extracts [J]. Food Drug（食品与药品）， 2005， 7(4)：20-22.
[7] HAN C H， HAN Y W， GONG H， et al. Inhibitory effects of extracts from Ginkgo biloba and grape seed on the generation of advanced glycation end products in vitro[J]. Chin Pharm J（中国药学杂志）， 2004，39(7)：507-509.
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脚注
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