目的 建立同时对全国主要产区生姜中 6- 姜酚、 6- 姜醇进行含量测定的方法。 方法 采用 Lichrospher C₁₈ 柱 （ 4.6 mm × 250 mm ， 5 μm ），以甲醇 - 水（ 65 ∶ 35 ）为流动相，体积流量 0.8 mL·min^-1 ，λ＝ 280 nm ，柱温 30 ℃ 。 结果 生姜中的 6- 姜酚与 6- 姜醇的线性范围和相关系数分别为 13.92~125.32 mg·L^-1 （ r = 0.999 9 ）， 4.04~36.40 mg·L^-1 （ r = 0.999 9 ）；加样回收率分别为 100.85% （ RSD=1.44% ）， 100.79% （ RSD=1.35% ）；方法精密度、重复性良好， RSD 均小于 2.0% 。 结论 本法操作简便、结果可靠、重现性好、检测快速、定量准确，可作为控制生姜质量的方法。

OBJECTIVE To establish a HPLC method for the simultaneous determination of 6-gingerol and 6-shogaol in Ginger from different districts in China. METHODS The samples were separated on a C18 column. The mobile phase was methanol-water（65∶35） at the flow rate of 0.8 mL·min-1. The detection wavelength was 280 nm. The column temperature was 30 ℃. RESULTS The linear range of 6-gingerol and 6-shogaol were 13.92 ~ 125.32 mg·L-1（r=0.999 9），4.04 ~ 36.40 mg·L-1（r= 0.999 9） respectively. The average recoveries were 100.85% and 100.79% with corresponding RSDs of 1.44% and 1.35%, respectively. The RSDs of precision and accuracy of the assay were not more than 2.0%(n=6). CONCLUSION The method is rapid, accurate, reliable and can be used for quality control of ginger.