[1] XU D H, HU Q H, LIANG W Q, <>et al. Effect of activity protectors on protein activity in microspheres[J]. <>Chin Pharm J( 中国药学杂志 ), 2007, 42(13):1003-1005.
[2] LANGER R. Biomaterials in drug delivery and tissue engineering: One laboratory's experience[J]. <>Account Chem Res, 2000, 33 (2): 94-101.
[3] JAIN J P, CHITKARA D, KUMAR N. Polyanhydrides as localized drug delivery carrier: an update[J]. <>Expert Opin Drug Deliv, 2008, 5(8): 889-907.
[4] JAIN J P, MODI S, DOMB A J, et al . Role of polyanhydrides as localized drug carriers[J]. <> J Controlled Release, 2005, 103(3): 541-563.
[5] KATTIA D S, LAKSHMIA S, LANGERB R, et al . Toxicity, biodegradation and elimination of polyanhydrides[J]. <>Adv Drug Deliv Rev, 54(7): 933-961.
[6] VOGEL B M, MALLAPRAGADA S K, NARASIMHAN B. Rapid synthesis of polyanhydrides by microwave polymerization[J]. <>Macromolecular Rapid Communications, 2004, 25(1): 330-333.
[7] ZHANG G, GUO S R. Synthesis of high molecular poly-sebacic anhydride[J]. <>Chin Pharm J( 中国药学杂志 ), 2005, 40(11):866-868.
[8] XU H B, CHEN Z X, HUANG K X, <>et al. The advances of polyanhydrides for controlled-release preparations[J]. <>Chin Pharm J ( 中国药学杂志 ), 2001, 36(2):76-80.
[9] LIU X H, PETTWAY G J, MCCAULEY L K, et al . Pulsatile release of parathyroid hormone from an implantable delivery system[J]. <>Biomaterials, 2007, 28(28): 4124-4131.
[10] SCHMIDT U, ZSCHOCHE S, WERNER C. Modification of poly (octadecene-alt-maleic anhydride) films by reaction with functional amines[J]. <> J Appl Polym Sci, 2003, 87(8): 1255-1266.
[11] HOU S, MCCAULEY L K, MA P X. Synthesis and erosion properties of PEG-containing polyanhydrides[J]. <>Macromolecular Bioscience, 2007, 7(5): 620-628.
[12] VOGEL B M, MALLAPRAGADA S K. Synthesis of novel biodegradable polyanhydrides containing aromatic and glycol functionality for tailoring of hydrophilicity in controlled drug delivery devices[J]. <>Biomaterials, 2005, 26(7): 721-728.
[13] ZHANG N, GUO S. Synthesis and micellization of amphiphilic poly(sebacic anhydride)-poly (ethylene glycol)-poly (sebacic anhydride) block copolymers[J]. <> J Polym Sci Part A-1, 2005, 44(3): 1271-1278.
[14] FIEGEL J, FU J, HANES J. Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs[J]. <> J Controlled Release, 2004, 96(3): 411-423.
[15] FU J, FIEGEL J, HANES J. Synthesis and characterization of PEG-based ether-anhydride terpolymers: novel polymers for controlled drug delivery[J]. <>Macromolecules, 2004, 37 (19): 7174-7180.
[16] TORRES M P, DETERMAN A S, ANDERSON G L, et al . Amphiphilic polyanhydrides for protein stabilization and release[J]. <>Biomaterials, 2007, 28(1): 108-116.
[17] KIPPER M J, WILSON J H, WANNEMUEHLER M J, et al . Single dose vaccine based on biodegradable polyanhydride microspheres can modulate immune response mechanism[J]. <> J Biomed Mater Res Part A, 2005, 76A (4): 798-810.
[18] ULERY B D, PHANSE Y, SINHA A, et al . Polymer chemistry influences monocytic uptake of polyanhydride nanospheres[J]. <>Pharm Res, 2009, 26(3): 683-690.
[19] DETERMAN A S, TREWYN B G, LIN V S Y, et al . Encapsulation, stabilization, and release of BSA-FITC from polyanhydride microspheres[J]. <> J Controlled Release, 2004, 100(1): 97-109.
[20] DETERMAN A S, GRAHAM J R, PFEIFFER K A ， et al . The role of microsphere fabrication methods on the stability and release kinetics of ovalbumin encapsulated in polyanhydride microspheres[J]. <> J Microencapsulation, 2006, 23(8): 832-843.
[21] MATHIOWITZ E, JACOB J S, JONG Y S, et al . Biologically erodable microspheres as potential oral drug delivery systems[J]. <>Nature, 1997, 386(6623): 410-414.
[22] FURTADO S, ABRAMSON D, BURRILL R, et al . Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres[J]. <>Inter J Pharm, 2008, 347(1-2): 149-155.
[23] SANDOR M, MEHTA S, HARRIS J, et al . Transfection of HEK cells via DNA-loaded PLGA and P(FASA) nanospheres[J]. <> J Drug Target, 2002, 10(6): 497-506.
[24] TABATA Y, GUTTA S, LANGER R. Controlled delivery systems for proteins using polyanhydride microspheres[J]. <>Pharm Res, 1993, 10(4): 487-496.
[25] WEINER A A, BOCK E A, GIPSON M E, et al . Photocrosslinked anhydride systems for long-term protein release[J]. <>Biomaterials, 2008, 29(15): 2400-2407.
[26] WEINER A A, MOORE M C, WALKER A H, et al . Modulation of protein release from photocrosslinked networks by gelatin microparticles[J]. <>Inter J Pharm, 2008, 360(1-2): 107-114.
[27] QUICK D J, MACDONALD K K, ANSETH K S. Delivering DNA from photocrosslinked, surface eroding polyanhydrides[J]. <> J Controlled Release, 2004, 97(2): 333-343.
[28] PFEIFER B A, BURDICK J A, LITTLE S R, et al . Poly(ester-anhydride):poly(β-amino ester) micro- and nanospheres: DNA encapsulation and cellular transfection[J]. <>Inter J Pharm, 2005, 304(1-2): 210-219.
[29] LI Y, JIANG H L, ZHU K J, et al . Preparation, characterization and nasal delivery of α-cobrotoxin-loaded poly(lactide-co-glycolide)/ polyanhydride microspheres[J]. <> J Controlled Release, 2005, 108(1): 10-20.
[30] LI Y, JIANG H L, JIN J F, et al . Bioadhesive fluorescent microspheres as visible carriers for local delivery of drugs. II: Uptake of insulin-loaded PCEFB/PLGA microspheres by the gastrointestinal tract[J]. <>Drug Deliv, 2004 , 11(6): 335-340.
[31] JIANG H L, ZHU K J. Bioadhesive fluorescent microspheres as visible carriers for local delivery of drugs. I: preparation and characterization of insulin-loaded PCEFB/PLGA microspheres[J]. <> J Microencapsulation, 2002, 19(4): 451-461.
[32] DETERMAN A S, WILSON J H, KIPPER M J, et al . Protein stability in the presence of polymer degradation products: Consequences for controlled release formulations[J]. <>Biomaterials, 2006, 27(17): 3312-3320.
（ 收稿日期 ： 2009-03-19 ）