药物分析研究方法的进展、应用与展望

张正行

中国药学杂志 ›› 2009, Vol. 44 ›› Issue (19) : 1454-1458.

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中国药学杂志 ›› 2009, Vol. 44 ›› Issue (19) : 1454-1458.
论文

药物分析研究方法的进展、应用与展望

  • 张正行
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摘要

药物是用于预防、治疗、诊断人的疾病,有目的地调节人的生理机能并规定有适应证和用法、用量的物质,药品质量的优劣直接影响到药品的安全性和有效性,关系到用药者的健康与生命安危。因此,必须运用各种有效手段,包括物理、化学、物理化学、生物学以及微生物学等方法,通过各个环节全面检测药品的真伪、纯度和品质,以使其安全、有效、稳定、可控。传统的药物分析,大多是应用化学方法分析药物分子,控制药品质量。随着分析化学的进步,特别是近年仪器分析和计算机技术的发展,为药物分析的进展提供了坚实的基础,药物分析学从静态发展到动态分析,从体外发展到体内分析,从品质分析发展到生物活性分析,从单一技术发展到联用技术,从小样本分析发展到高通量分析,从人工分析发展到计算机辅助分析,使得药物分析从 20 世纪初的一种专门技术,逐步发展成为一门日臻成熟的科 学 —— 药物分析学。药物分析学涉及的研究范围包括药物质量控制、临床药学、中药与天然药物分析、药物代谢分析、法医毒物分析、兴奋剂检测和药物制剂分析、创新药物研究,以及药品上市后的再评价等,哪里有药物,哪里就有药物分 析 [1] 。为此,笔者和同仁曾撰文就现代药物分析方法其研究对象进行阐述 [2-4] ,本文在此基础上,重点就与药物质量控制和新药研发关系密切药物分析方法的研究进展及其应用并结合建国后出版的历版中国药典收载的质量标准和方法,进行了介绍,以此在庆祝中国成立 60 年之际,展示我们分析化学和药物分析进展及其工作者对现代药物分析方法研究和应用在国际和国内的作用和贡献。

关键词

药物分析 / 进展 / 展望

引用本文

导出引用
张正行 . 药物分析研究方法的进展、应用与展望[J]. 中国药学杂志, 2009, 44(19): 1454-1458

参考文献


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( 收稿日期 : 2009-08-31 )

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