OBJECTIVE To synthesize palonosetron hydrochloride.METHODS Palonosetron hydrochloride was prepared from(S)-3-amino-quinuclidine and(S)-1,2,3.4-tetrahydro-l-naphalenecarboxylic acid as a starting material via three steps including acylation,reduction,and cyclization.RESULTS The total yield of palonosetron hydrochloride was 76%. CONCLUSION The easily manipulated and reliable procedure to synthesize palonosetron hydrochloride is applicable.
TNG Tin;WU Yong-fu.
Synthesis of Palonosetron Hydrochloride [J]. Chinese Pharmaceutical Journal, 2009, 44(10): 794-795
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