摘要
目的考察马钱子碱在大鼠体内的药动学性质。方法考察不同给药途径对马钱子碱在大鼠体内药动学的影响。HPLC测定静脉注射、灌胃和腹腔注射10 mg·kg-1马钱子碱溶液后不同时间点的血药浓度。药动学参数采用3P97程序进行拟合。结果马钱子碱溶液灌胃和腹腔注射给药的绝对生物利用度分别为33.3%和74.9%。与静脉注射相比,灌胃和腹腔注射后的药动学特性发生显著改变。静脉注射和灌胃给药后的体内药动学符合二室模型,但腹腔注射符合一室模型。结论给药途径是影响马钱子碱体内药动学性质的重要因素。
Abstract
OBJECTIVE To investigate pharmacokinetic properties of brucine in rats.METHODS The effect of administration route on pharmacokinetics of brucine was studied in rats.A single dose of 10 mg·kg-1 brucine solution was given by iv,ig or ip route.Plasma samples were drawn at intervals and the concentrations were determined by a validated HPLC method. Pharmacokinetic analysis was performed by 3P97 program.RESULTS The absolute bioavailabilities of ig and ip administration route were 33.3%and 74.9%.respectively.After ig or ip administration,pharmacokinetic characteristics were significantly changed, compared with iv route.The pharmacokinetic behavior after iv and ig administration was fitted with a two-compartment model, while ip administration was fitted with one-compartment model.CONCLUSION The administration route is the key factor which influences the pharmacokinetics of brucine in vivo.
关键词
马钱子碱 /
药动学 /
高效液相色谱法
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Key words
brucine /
pharmacokinetics /
HPLC
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陈军;胡巍;蔡宝昌;楼成华;王立杰;王玮.
马钱子碱在大鼠体内的药动学[J]. 中国药学杂志, 2009, 44(10): 778-780
CHEN Jun;HU Wei;CI o-chng;LOU Cheng-hu;WNG Li-jie;WNG Wei.
Pharmacokinetics of Brucine in Rats [J]. Chinese Pharmaceutical Journal, 2009, 44(10): 778-780
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参考文献
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脚注
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基金
国家自然科学基金资助项目(重大研究计划90209052;面上项目30701111)
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