OBJECTIVE To research the effects of EGB on insulin resistance improvement and discuss the mechanism by observing the effects of Ginkgo biloba extract(EGB) on the expression of GLUT4 mRNA in the skeletal muscle of type 2 diabetic rats.METHODS The model of type 2 diabetes was established by feeding high sucrose-fat diet and injecting small does streptozotocin into abdomen.Then the oral glucose tolerance(OGTT) and serum insulin(INS) were measured.The insulin resistance index(HOMA-IR) was calculated.The expression of GLUT4 mRNA in the skeletal muscle of the rats was examined by RT-PCR.RESULTS EGB obviously improved OGTT,decreased INS,increased the expression of GLUT4 mRNA in the skeletal muscle of the rats and decreased insulin resistance index(HOMA-IR).CONCLUSION EGB could decrease blood glucose and insulin,improve insulin resistance(IR),and could prevent and treat the diabetes and complications of diabetes effectively.
LIU Xin;LI Xin;TONG Yu.
Effects of Ginkgo Biloba Extract on the Expression of GLUT4 mRNA in the Skeletal Muscle of Type 2 Diabetic Rats [J]. Chinese Pharmaceutical Journal, 2009, 44(10): 747-750
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