摘要
目的研究南海软珊瑚Dendronephthya gigantea的化学成分。方法采用柱层析法、Sephadex LH-20和反相半制备HPLC等方法分离化合物,根据波谱数据和理化常数确定其结构。结果从南海软珊瑚Dendronephthya gigantea分离得到10个化合物,鉴定为:(4E,8E)-2(hexadecanoylamino)-4,8-octadecadiene-1,3-diol(1),(4E)-2(hexadecanoylamino)-4-octadecane-1, 3-diol(2),乙酰基苯乙胺(3),Cyclo-(Leu-Pro)(4),Cyclo-(Ala-Pro)(5),Cyclo-(Val-Pro)(6),2,4-二氯苯甲酸(7),胸腺嘧啶脱氧核苷(8),胞嘧啶脱氧核苷(9),胆甾醇(10)。结论其中化合物1～9为首次从软珊瑚Dendronephthya gigantea中分离得到。
Abstract
OBJECTIVE To study the chemical constituents of Dendronephthya gigantea.METHODS The compounds were isolated and purified by silica gel,Sephadex LH-20,and semi-preparative reverse-phase HPLC.Their structures were identified by their physical and spectral data.RESULTS Ten compounds were isolated from Dendronephthya gigantea and their structures were identified as(4E,8E)-2(hexadecanoylamino)-4,8-octadecadiene-1,3-diol(1),(4E)-2(hexadecanoylamino)-4-octad- ecane-1,3-diol (2),N-phenethylacetamide(3),Cyclo-(Leu-Pro)(4),Cyclo-(Ala-Pro)(5),Cyclo-(Val-Pro)(6),2,4-dichlorobenzoic acid(7),thymidine (8),2'-deoxyuride(9),cholesterol(10).CONCLUSION Compound 1-9 were isolated from Dendronephthya gigantea for the first time.
关键词
软珊瑚 /
Dendronephthyagigantea /
化学成分
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Key words
soft coral /
Dendronephthya gigantea /
chemical constituents
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王应莉;廖小建;徐石海.
南海软珊瑚Dendronephthya gigantea的化学成分研究[J]. 中国药学杂志, 2009, 44(10): 740-742
WNG Ying-li;LIO Xio-jin;XU Shi-hi.
Study on Chemical Constituents of Soft Coral Dendronephthya gigantea from the South China Sea [J]. Chinese Pharmaceutical Journal, 2009, 44(10): 740-742
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脚注
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基金
国家863基金项目(2006AA09Z408);国家自然科学基金资助项目(20772048);广东省自然科学基金资助项目(06025194)
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