摘要
目的介绍喷雾冷冻干燥技术及其在药剂学中的应用进展。方法结合最新文献和实验中对喷雾冷冻干燥技术的体会,做出归纳总结。结果与结论喷雾冷冻干燥技术作为一种新的固体分散体制备技术,为改善难溶性药物的溶出和BCSⅡ类(高脂溶性和高透膜性)药物的体内生物利用度提供了很好的解决办法,也为开发生物制剂和吸入给药制剂提供了一个技术手段。
关键词
喷雾冷冻干燥 /
固体分散体 /
溶出度 /
脂溶性药物
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杜祯;郑颖;黎畅明;王一涛;唐海谊.
喷雾冷冻干燥技术进展及其在药剂学中的应用[J]. 中国药学杂志, 2009, 44(10): 724-727
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脚注
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基金
澳门科学技术发展基金资助(005/2007/A1)
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