喷雾冷冻干燥技术进展及其在药剂学中的应用

杜祯;郑颖;黎畅明;王一涛;唐海谊

中国药学杂志 ›› 2009, Vol. 44 ›› Issue (10) : 724-727.

中国药学杂志 ›› 2009, Vol. 44 ›› Issue (10) : 724-727.
综述

喷雾冷冻干燥技术进展及其在药剂学中的应用

  • 杜祯;郑颖;黎畅明;王一涛;唐海谊
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摘要

目的介绍喷雾冷冻干燥技术及其在药剂学中的应用进展。方法结合最新文献和实验中对喷雾冷冻干燥技术的体会,做出归纳总结。结果与结论喷雾冷冻干燥技术作为一种新的固体分散体制备技术,为改善难溶性药物的溶出和BCSⅡ类(高脂溶性和高透膜性)药物的体内生物利用度提供了很好的解决办法,也为开发生物制剂和吸入给药制剂提供了一个技术手段。

关键词

喷雾冷冻干燥 / 固体分散体 / 溶出度 / 脂溶性药物

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杜祯;郑颖;黎畅明;王一涛;唐海谊. 喷雾冷冻干燥技术进展及其在药剂学中的应用[J]. 中国药学杂志, 2009, 44(10): 724-727

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基金

澳门科学技术发展基金资助(005/2007/A1)

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