摘要
目的综述黄酮类化合物在防治高尿酸血症和痛风方面的研究进展。方法依据近十年来国内外文献,进行分析、归纳和总结。结果与结论黄酮类化合物可以通过多种机制和多个靶点防治高尿酸血症和痛风。已经阐明的药理作用机制包括:通过抑制黄嘌呤氧化酶活性,促进尿酸排泄来防治高尿酸血症;通过抑制中性粒细胞中炎性递质的释放,抑制尿酸盐结晶诱导的炎性细胞因子的分泌及其基因表达来防治痛风性关节炎。
关键词
黄酮类化合物 /
高尿酸血症 /
痛风性关节炎 /
嘌呤代谢
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夏道宗;张英;吕圭源.
黄酮类化合物防治高尿酸血症和痛风的研究进展[J]. 中国药学杂志, 2009, 44(10): 721-723
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脚注
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基金
浙江省自然科学基金资助项目(Y207783);杭州市科研攻关项目(20062413B27)
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