摘要
目的以聚乙烯吡咯烷酮(PVP)、聚乙二醇(PEG)为载体,分别制备了姜黄素固体分散体。以姜黄素的普通片剂为参比制剂,研究固体分散体在大鼠体内的药动学过程。方法SD大鼠分别灌胃给予姜黄素固体分散体及姜黄素片剂,采用高效液相色谱法测定姜黄素的血药浓度,使用3P97软件计算药动学参数。结果姜黄素固体分散体在大鼠体内药动学过程符合单室模型,与姜黄素普通片剂相比ρmax,AUC显著增大,姜黄素-PVP固体分散体相对生物利用度为690%。结论姜黄素-PVP固体分散体能显著提高姜黄素在大鼠体内的生物利用度。
Abstract
OBJECTIVE To prepare curcumin solid dispersion with Polyvinylpyrrolidone(PVP) and Polyethylene glycol(PEG),and to study the pharmacokinetics of curcumin solid dispersion in rats were used curcumin tablet as reference preparation.METHODS The rats were fed with curcumin solid dispersion and tablet.The curcumin concentration in whole blood was determined by HPLC.The date was processed by the 3P97.RESULTS The concentration-time curves of curcumin solid dispersion were diseribed with one-compartment model,The total areas under the plasma concentration-time curve AUC were larger than that of tablets and its bioavailability was 690%.CONCLUSION The curcumin solid dispersion could increase bioavailability in rats in vivo remarkably.
关键词
姜黄素 /
固体分散体 /
药动学 /
聚乙烯吡咯烷酮 /
聚乙二醇
{{custom_keyword}} /
Key words
curcumin /
solid dispersion /
pharmacokinetics /
polyvinylpyrrolidone /
polyethylene glycol
{{custom_keyword}} /
韩刚;翟丽;赵琳琳;刘莉;林庆辉;毕瑞.
姜黄素固体分散体在大鼠体内的药动学研究[J]. 中国药学杂志, 2009, 44(09): 698-700
HN Gng;ZHI Li;ZHO Lin-lin;LIU Li;LIN Qing-hui;I Rui.
Pharmacokinetics of Curcumin Solid Dispersion in Rats in vivo[J]. Chinese Pharmaceutical Journal, 2009, 44(09): 698-700
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] LIU A C，LOU H X，ZHAO L X，et al. Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipids complex of curcumin [J]. J Pharm Biomed Anal，2006，40(3)：720-727.
[2] HAN G，WANG C S，ZHANG Y，et al. Study on the solid dispersion increase solubility of curcumin [J]. Chin J Mater Med（中国中药杂志），2007，32（7）：637-638.
[3] SHOBA G，JOY D，JOSEPH T，et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers [J]. J Planta Med，1998，64(4)：353-356.
[4] HAN G，AN J，WANG B Q. Quality standard for Tongmaijiangzhi capsule[J]. Chin Tradit Patent Med（中成药），2005，27(7)：778-780.
[5] YAN R X. Water-Soluble Polymer(水溶性高分子)[M]. Beijing：Chemicals Industry Press，2001：602-604.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
