siRNA分子非病毒载体的生物体内给药系统

曹波;季爱民

中国药学杂志 ›› 2009, Vol. 44 ›› Issue (09) : 641-644.

中国药学杂志 ›› 2009, Vol. 44 ›› Issue (09) : 641-644.
综述

siRNA分子非病毒载体的生物体内给药系统

  • 曹波;季爱民
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摘要

目的综述小分子干扰RNA(small interfering RNA,siRNA)经非病毒载体介导生物体内给药的研究进展。方法查阅国内外相关文献,进行分析、归纳和综述。结果与结论siRNA分子由于其本身的特性,生物体内给药必须借助合适的给药系统,相对病毒载体,非病毒载体具有简便,安全和毒性小等特点,易于为临床所接受,因而近年来发展迅速。

关键词

小分子干扰RNA / 非病毒载体

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曹波;季爱民. siRNA分子非病毒载体的生物体内给药系统[J]. 中国药学杂志, 2009, 44(09): 641-644

参考文献

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基金

国家自然科学基金资助项目(30672557);广东省自然科学基金重点项目(8251051501000008)

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