摘要
目的综述近几年载脂蛋白修饰聚氰基丙烯酸丁酯纳米粒(polybutylcyanoacrylate nanoparticles,PBCA-NP)在跨血脑屏障入脑研究进展。方法检索近年来国内外有关载脂蛋白修饰纳米粒和血脑屏障的研究性文献,并进行分析、归纳。结果概述了载脂蛋白修饰的PBCA纳米粒在体内外跨血脑屏障研究中的研究成果,并对其入脑机制进行了探讨。结论载脂蛋白PBCA纳米粒必将成为一种重要的脑靶向载体。
关键词
载脂蛋白 /
PBCA纳米粒 /
血脑屏障
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柴国宝;冯健;李范珠.
载脂蛋白修饰聚氰基丙烯酸丁酯纳米粒介导药物跨血脑屏障的研究进展[J]. 中国药学杂志, 2009, 44(08): 561-563
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脚注
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