载脂蛋白修饰聚氰基丙烯酸丁酯纳米粒介导药物跨血脑屏障的研究进展

柴国宝;冯健;李范珠

中国药学杂志 ›› 2009, Vol. 44 ›› Issue (08) : 561-563.

中国药学杂志 ›› 2009, Vol. 44 ›› Issue (08) : 561-563.
综述

载脂蛋白修饰聚氰基丙烯酸丁酯纳米粒介导药物跨血脑屏障的研究进展

  • 柴国宝;冯健;李范珠
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摘要

目的综述近几年载脂蛋白修饰聚氰基丙烯酸丁酯纳米粒(polybutylcyanoacrylate nanoparticles,PBCA-NP)在跨血脑屏障入脑研究进展。方法检索近年来国内外有关载脂蛋白修饰纳米粒和血脑屏障的研究性文献,并进行分析、归纳。结果概述了载脂蛋白修饰的PBCA纳米粒在体内外跨血脑屏障研究中的研究成果,并对其入脑机制进行了探讨。结论载脂蛋白PBCA纳米粒必将成为一种重要的脑靶向载体。

关键词

载脂蛋白 / PBCA纳米粒 / 血脑屏障

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柴国宝;冯健;李范珠. 载脂蛋白修饰聚氰基丙烯酸丁酯纳米粒介导药物跨血脑屏障的研究进展[J]. 中国药学杂志, 2009, 44(08): 561-563

参考文献

[1] KREUTER J. Nanoparticles--a historical perspective[J]. Int J Pharm,2007,331(1):1-10. [2] IBRAHIM A,COUVREUR P,SPEISER P,et al. New magnetic drug carrier[J]. J Pharm Pharmacol,1983,35(1):59-61. [3] OLIVIER J C. Drug transport to brain with targeted nanoparticles[J]. Neuro Rx,2005,2(1):108-119. [4] KREUTER J. Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain[J]. J Nanosci Nanotechnol,2004,4(5):484-488. [5] KREUTER J. Nanoparticulate systems for brain delivery of drugs[J]. Adv Drug Deliv Rev,2001,47(1):65-81. [6] KREUTER J,SHAMENKOV D,PETROV V,et al. Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier[J]. J Drug Target,2002,10(4):317-325. [7] SUZUKI T,ZAIMA C,MORIKI Y,et al. P-glycoprotein mediates brain-to-blood efflux transport of buprenorphine across the blood-brain barrier[J]. J Drug Target,2007,15(1):67-74. [8] BAO S Y. Blood-brain barrier A barrier in front of neuroscientists [J]. Int J Cerebrovasc Dis(国际脑血管病杂志),2006,14(2):81-83. [9] YANG Z Y,LIU G Q. Effect of p-glycoprotein inhibitor combinations on drug efflux from rat brain microvessel endothelial cells[J]. Pharmazie,2004,59(12):952-956. [10] JIN X H,BAO S Y. P-Glycoprotein and Blood-Brain Barrier[J]. Int J Cerebrovasc Dis(国际脑血管病杂志),2006,14(4):282-285. [11] LOCKMAN P R,MUMPER R J,KHAN M A,et al. Nanoparticle technology for drug delivery across the blood-brain barrier[J]. Drug Dev Ind Pharm,2002,28(1):1-13. [12] LOCKMAN P R. Nanoparticle surface charges alter blood-brain barrier integrity and permeability[J]. J Drug Target,2004,12(9-10):635-641. [13] SILVA G A. Nanotechnology approaches for drug and small molecule delivery across the blood brain barrier[J],Surg Neurol 2007,67(2):113-116. [14] LU W,ZHANG Y,TAN Y Z,et al. Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery[J]. J Controlled Release,2005,107(3):428-448. [15] XING X Q,TAO T,CHEN Q H. Recent advances of drug delivery systems across blood-brain barrier[J]. Chin New Drugs J(中国新药杂志),2002,11 (7):519-523. [16] LIU-SNYDER P,WEBSTER T J. Designing drug-delivery systems for the nervous system using nanotechnology:opportunities and challenges[J]. Expert Rev Med Devices,2006,3(6):683-687. [17] KOZIARA J M,LOCKMAN P R,ALLEN D D,et al. In situ blood-brain barrier transport of nanoparticles[J]. Pharm Res,2003,20(11):1772-1778. [18] JAIN K K. Use of nanoparticles for drug delivery in glioblastoma multiforme[J]. Expert Rev Neurother,2007,7(4):363-372. [19] KUO Y C,CHEN H H. Effect of nanoparticulate polybutylcyanoacrylate and methylmethacrylate-sulfopropylme- thacrylate on the permeability of zidovudine and lamivudine across the in vitro blood-brain barrier[J]. Int J Pharm,2006,327(1-2):160-169. [20] LOHBACH C,NEUMANN D,LEHR C M,et al. Human vascular endothelial cells in primary cell culture for the evaluation of nanoparticle bioadhesion[J]. J Nanosci Nanotechnol,2006,6(9):3303-3309. [21] GARCIA-GARCIA E,GIL S,ANDRIEUX K,et al. A methodology to study intracellular distribution of nanoparticles in brain endothelial cells[J]. Int J Pharm,2005,298(2):310-314. [22] HANABE W,MAEDA T,FUKAZAWA Y, et al. P-glycoprotein ATPase activating effect of opioid analgesics and their P-glycoprotein-dependent antinociception in mice[J]. Pharmacol Biochem Behav,2006,85(6):629-636. [23] KREUTER J,RAMGE P,PETROV V,et al. Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles[J]. Pharm Res,2003,20(3):409-416. [24] KIM H R,GIL S,ANDRIEUX K,et al. Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells[J]. Cell Mol Life Sci,2007,64(3):356-364. [25] KREUTER J,HEKMATARA T,DREIS S,et al. Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain[J]. J Controlled Release,2007,118(1):54-58. [26] NIKANJAM M,BLAKELY E A,BJORNSTAD K A,et al. Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme [J]. Int J Pharm,2007,328(1):86-94. [27] PETRI B,BOOTZ A,KHALANSKY A,et al. Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles:revisiting the role of surfactants[J]. J Controlled Release,2007,117(1):51-58. [28] KIM H R,ANDRIEUX K,GIL S,et al.Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells:role of apolipoproteins in receptor-mediated endocytosis[J]. Biomacromolecules,2007,8(3):793-799. [29] KRATZER I,WERNIG K,PANZENBOECK U,et al. Apolipoprotein A-I coating of protamine-oligonucleotide nanoparticles increases particle uptake and transcytosis in an in vitro model of the blood-brain barrier[J]. J Controlled Release,2007,17(3):301-311.

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