OBJECTIVE To study the synthetic process for bretazenil. METHODS Bretazenil was synthesized from 3-bromoaniline by cyclization, oxidation and ring-enlargement reaction, etc.RESULTS The purity of the product was above 99%. The structure of bretazenil was verified by 1H-NMR. The overall yield was 12.4%, which was higher than reported yield(4.8%). CONCLUSION It is proved to be a method with mild condition, high quality and good yield.
LI Li-wei;CHENG Zhi-gng;M Xue-gong.
Synthesis of Bretazenil [J]. Chinese Pharmaceutical Journal, 2008, 43(16): 1275-1277
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