菊状千里光的化学成分研究

张朝凤;金军;张勉

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (16) : 1214-1217.

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (16) : 1214-1217.
论著

菊状千里光的化学成分研究

  • 张朝凤;金军;张勉
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Studies on Chemical Constituents of Senecio laetus Edgew.

  • ZHANG Chao-feng,JIN Jun,ZHANG Mian
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摘要

目的为系统研究千里光属药用植物的活性或毒性成分,对菊状千里光(Senecio laetus Edgew.)全草进行化学成分研究。方法采用体积分数为90%乙醇热回流提取,分别采用溶剂萃取和硅胶、Sephadex LH-20柱色谱分离等方法得到11个化合物,通过波谱解析和理化常数鉴定其结构。结果从总生物碱部位分得3个化合物:奥索千里光碱(1)、千里光碱(2)和千里光菲灵碱(3);从非生物碱部位得到4个黄酮类和4个有机酸类化合物:异鼠李素-3-O-β-D-半乳糖苷(4)、异鼠李素(5),槲皮素(6),黄颜木素(7),白藓苷A(8)、2-(4′-羟基-3′,5′-二甲氧基苯基)-1,3-丙二醇(9)、香草酸(vanillic acid,10)和对羟基苯乙酸(11)。结论化合物9为新天然产物,化合物7和8为首次属内分离得到,其余化合物均为首次从该种植物中分离得到。

Abstract

OBJECTIVE To investigate the active or toxicity constituents of Senecio laetus Edgew. METHODS The compounds were extracted with 90% EtOH and isolated and purified by means of chromatography. Compound were identified by their physical characteristics and spectral features. RESULTS Eleven compounds were isolated and identified as otosenine (1), senecionine (2), seneciphylline (3), isorhamnetin-3-O-β-D-galactoside (4), isorhamnetin (5), quercetin (6), fisetin (7), dictamnoside (8), 2-(4'-hydroxy-3', 5'-imethoxyphenyl)-3-propanediol (9), vanillic acid (10) and p-hydroxyphenylacetic acid (11). CONCLUSION Compound 9 was firstly obtained from natural plants, compound 7 and 8 were isolated from this genus for the first time.

关键词

菊状千里光 / 吡咯里西啶生物碱 / 黄酮 / 有机酸

Key words

Senecio laetus Edgew. / pyrrolizidine alkaloids(HPAs) / flavonoids / organic acid

引用本文

导出引用
张朝凤;金军;张勉. 菊状千里光的化学成分研究[J]. 中国药学杂志, 2008, 43(16): 1214-1217
ZHNG Cho-feng;JIN Jun;ZHNG Min. Studies on Chemical Constituents of Senecio laetus Edgew. [J]. Chinese Pharmaceutical Journal, 2008, 43(16): 1214-1217

参考文献

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基金

国家“十五重大科技专项”资助项目(2004AA2Z3730-15)

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