目的综述了近年来RNA干扰技术在抗人免疫缺陷病毒(HIV)感染中的作用靶点。方法以近几年具有代表性的文献为依据,进行分析、归纳和整理。结果与结论目前RNA干扰技术已广泛应用于HIV复制周期中的多个环节。RNAi不但可以靶向HIV基因组,而且可以通过降低多个与HIV复制密切相关且宿主非必需性的细胞因子的表达达到抑制HIV的目的。RNAi在抗HIV领域的广泛应用,必将成为解决病毒耐药性的问题、进而攻克艾滋病的有力武器。
关键词
人免疫缺陷病毒 /
RNA干扰 /
基因治疗 /
小干扰RNA /
基因沉默
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脚注
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基金
国家自然科学基金资助项目(30371686,30772692);国际合作重点项目(2003DF000033);教育部博士点基金(070422083);山东省自然科学基金资助项目(Y2003C11);济南市科技攻关计划(200705100)
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