目的对钩枝藤茎、枝的化学成分进行研究。方法采用氧化铝柱色谱,硅胶柱色谱,Sephadex LH-20凝胶柱色谱进行分离,通过理化和波谱分析鉴定结构。结果分离并鉴定了7生物碱个化合物。分别为ancistrobertsonine B(1),an- cistrotectorine(2),(1S,3S)-5-(4,5-二甲氧基-2-甲基萘-1-基)-6,8-二甲氧基-1,3-二甲基-1,2,3,4-四氢异喹啉(3),(1S,3R)-5-(4,5-二甲氧基-2-甲基萘-1-基)-6,8-二甲氧基-1,3-二甲基-1,2,3,4-四氢异喹啉(4),ancistro- cline(5),ancistrocladinine(6),hamatinine(7)。结论化合物1,3,4,6,7均为首次从该植物中分离得到。
Abstract
OBJECTIVE To study the chemical constituents of the stems and branches of Ancistrocladus tectorius.METHODS The constituents were isolated and purified by chromatography on aluminium oxide,silica gel and Sephadex LH-20 column.Their structures were identified by physicochemical properties and spectral analysis.RESULTS Seven alkaloids compounds were isolated and identified as ancistrobertsonine B(1),ancistrotectorine(2),(1S,3S)-5-(4,5-dimethoxy-2-methyl-naphthalen-1-yl)-6,8- dimethoxy-1,3-dimethyl-1,2,3,4-tetrahydruisoquinoline(3),(1S,3R)-5-(4,5-dimethoxy-2-methylnaphthalen-1-yl)-6,8- dimethoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline(4),ancistrocline(5),ancistrocladinine(6),hamatinine(7). CONCLUSION Compounds 1,3,4,6 and 7 were isolated from this plant for the first time.
关键词
钩枝藤 /
化学成分
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Key words
Ancistrocladus tectorius /
chemical constituents /
alkaloids
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参考文献
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[3] GERHARD B，CHRISTIAN G，STEFAN B，et al. Ancistroguineines A and B as well as ancistrotectorine-naphthylisoquinoline alkaloids from Ancistrocladus guinensis[J] .Phytochemistry，1998，47(1)：37-43.
[4] FOUCHER J P，POUSSET J L，CAVE A. L′Ancistrocladonine et L′Ancistroealaensine deux alcaloides nouveaux isles de L′Ancistrocladus ealaensis[J] .Phytochemistry，1974，13（7）：1253-1256.
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脚注
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基金
2005年度海口市重点科技计划项目;海南省重点学科-药物化学建设基金
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