摘要
目的研究中药款冬花的化学成分。方法采用硅胶、Sephadex LH-20柱色谱等方法分离化合物,根据波谱数据和理化常数确定其结构。结果从款冬花中分离得到11个化合物,鉴定为:克氏千里光碱(senkirkine,1)、款冬酮(tussilagone,2)、款冬巴耳二醇(bauer-7-ene-3β,16α-diol,3)、sitoindosideΙ(4)、pedatisectineE(5)、β-carboline(6)、苯甲酰胺(benzamide,7)、腺嘌呤核苷(adenosine,8)、正二十七酸(heptacosanoic acid,9)、β-谷甾醇(β-sitoterol,10)和胡萝卜苷(daucosterol,11)。结论化合物1,4,5,6,7,9,10为首次从款冬中分离得到,其中4,5,6为首次从菊科植物中分离得到。化合物1和2对组胺和乙酰胆碱诱导的豚鼠离体气管条痉挛有抑制作用。
Abstract
OBJECTIVE To investigate the chemical constituents of the flower buds of Tussilago farfara L.METHODS The chemical constituents were isolated by silica gel and Sephadex LH-20 column chromatography,and structurally elucidated by spectral evidence and physiochemical analysis.RESULTS Eleven compounds were isolated from the flower buds of Tussilago farfara,and their structures were identified as senkirkine(1),tussilagone(2),bauer-7-ene-3β,16α-diol(3),sitoindoside Ι(4),pedatisectine E(5),β-carboline(6),benzamide(7),adenosine(8),heptacosanoic acid(9),β-sitoterol(10) and daucosterol(11).CONCLUSION Compounds 4,5 and 6 were isolated from the Compositae for the first time,and compounds 1,7,9 and 11 were isolated from the plant for the first time.Compound 1 and 2 significantly inhibited the contractile response of the isolated tracheal smooth muscle strip of guinea pig induced by histamine and acetylcholine.
关键词
菊科 /
款冬花 /
化学成分 /
生物活性
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Key words
Compositae /
Tussilago farfara /
chemical constituents /
bioactivity
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吴笛;张朝凤;张勉;张建伟;王峥涛.
中药款冬花的化学成分研究[J]. 中国药学杂志, 2008, 43(04): 260-263
WU Di;ZHNG Cho-feng;ZHNG Min;ZHNG Jin-wei;WNG Zheng-to.
Study on Chemical Constituents of the Flower Buds of Tussilago farfara[J]. Chinese Pharmaceutical Journal, 2008, 43(04): 260-263
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脚注
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