蒙特卡罗模拟在抗生素药动学和药效学中的应用

张波;朱珠

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (04) : 241-244.

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (04) : 241-244.
综述

蒙特卡罗模拟在抗生素药动学和药效学中的应用

  • 张波;朱珠
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摘要

目的介绍近年来国内外蒙特卡罗模拟在抗生素药动学和药效学中的作用。方法以美国哈特福德抗生素研究和发展中心的OPTAMA研究为例,对蒙特卡罗模拟在抗生素药动学和药效学中的应用进行综合、分析和归纳。结果蒙特卡罗模拟作为一种利用随机数字或伪随机数字的统计取样方法,可以将抗生素的药动学(患者药动学参数)和药效学(MIC数据)有机结合,它可以预测抗生素给药方案的目标获得概率(probability of target attainment,PTA)。结论蒙特卡罗模拟为抗生素药动学和药效学研究提供了一种新的方法,可为抗生素经验治疗和个体化治疗提供合理给药方案。

关键词

抗生素 / 蒙特卡罗模拟 / 药动学 / 药效学 / OPTAMA

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张波;朱珠. 蒙特卡罗模拟在抗生素药动学和药效学中的应用[J]. 中国药学杂志, 2008, 43(04): 241-244

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