Determination of Urinary Isatin in Patients with Cancer and Its Clinical Significance
SUN Wei1，LI Dong-mei1，LI Jing1，LI Ya-juan1，YU Guo-ying1，MENG De-bao1，YUE Wang2
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1.Pharmaceutical Department，Afflicated Hospital of Medical College，Qingdao Universitity，Qingdao 266003，China；2.Pharmacology Department，Medical College of Qingdao Universitity，Qingdao 266003，China
OBJECTIVE To develop a HPLC assay for determination of urinary isatin in cancer patients.METHODS The urinary isatin in 55 malignant tumor patients and 15 healthy volunteers were determined by HPLC.RESULTS The isatin quantification in cancer group,especially the abdominal cancer was significantly higher than that of control group(P<0.05,P<0.001).The isatin concentration in patients with abdominal cancer group,was significantly higher than that of patients with thoracic or urinary cancer.For thoracic cancer patients,there was no significant difference in isatin concentration in urine between before are after operation,and among different TNM stages.CONCLUSION The isatin concentration of urine might serve as a novel tumor diagnosis marker.
SUN Wei;LI Dong-mei;LI Jing;LI Y-jun;YU Guo-ying;MENG De-o;YUE Wng.
Determination of Urinary Isatin in Patients with Cancer and Its Clinical Significance [J]. Chinese Pharmaceutical Journal, 2008, 43(02): 149-151
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参考文献
[1] KAMINSKI K A，BODZIONY J，KOZIELSKI J . Monitoring treatment of pulmonary carcinomas by serial determination of monoamine oxidase and diamine oxidase in blood serum[J] .Arch Geschwulstforsch，1984，54(5)：377-385.
[2] GLOVER V，REVELEY M A，SANDLER M. A monoamine oxidase inhibitor inhuman urine[J] . Biochem Pharmacol，1980，29(3)：467-470.
[3] LI J，SUN W，LI Y J，et al.Study on isatin in urine as the marker of parkinson’s disease[J] .Chin Pharm J(中国药学杂志)，2004，39(10)：776-778.
[4] GERLACH M，DESSER H，YHOUDIM M B，et al.New horizons in molecular echanisms underlying Parkinson'd isease and in our understanding of the neyroprotective effects of selegine[J] . Neurol Transm，1996，48：7-9.
[5] CUI X，ZHANG B W，LI W B，et al. The antioxidative effect of monoamine oxidase B inhibitors on aging model mice induced by D galactose[J] .Chin J Psychiatry(中华精神科杂志)，1999，32(3)：139-141.
