摘要
目的研究氧化苦参碱缓释片在Beagle犬体内的代谢及其相对生物利用度。方法采用单剂量双周期自身交叉设计,分别给犬单剂量灌胃氧化苦参碱缓释片或胶囊,用LC-MS测定给药后的血浆中氧化苦参碱和其代谢物苦参碱浓度。结果氧化苦参碱缓释片中氧化苦参碱、代谢物苦参碱的相对生物利用度分别为(73.9±2.1)%和(122.0±11.7)%。结论以氧化苦参碱或代谢物苦参碱为统计指标,氧化苦参碱缓释片和胶囊在吸收程度上生物不等效。
Abstract
OBJECTIVE To study metabolism and relative bioavailability of oxymatrine sustained-release tablets in Beagle dogs.METHODS A cross-over design was used.Plasma concentration of oxymatrine and metabolite matrine were determined by LC/MS method after Beagle dogs were administrated with a single dose of 300 mg oxymatrine sustained-release tablets or oxymatrine capsules.RESULTS The relative bioavailability of oxymatrine and metabolite matrine in Beagle dogs were(73.9±2.1)% and(122.0±11.7)%,respectively.CONCLUSION Oxymatrine sustained-release tablets were unbioequivalent to oxymatrine capsules when the absorption of oxymatrine or its metabolite matrine was taken as the index.
关键词
氧化苦参碱缓释片 /
氧化苦参碱胶囊 /
苦参碱 /
相对生物利用度
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Key words
oxymatrine sustained-release tablets /
oxymatrine capsules /
matrine /
relative bioavailability
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王素军;王广基;李晓天;阮金秀;张振清.
氧化苦参碱缓释片在犬体内的代谢及其相对生物利用度[J]. 中国药学杂志, 2008, 43(02): 129-131
WNG Su-jun;WNG Gung-ji;LI Xio-tin;RUN Jin-xiu;ZHNG Zhen-qing.
Metabolism and Relative Bioavailability of Oxymatrine Sustained-Release Tablets in Beagle Dogs [J]. Chinese Pharmaceutical Journal, 2008, 43(02): 129-131
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参考文献
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脚注
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