1.College of Life Science，Soochow University，Jiangsu Suzhou 215123，China；2. College of Veterinary Medicine，Northwest A & F University，Shanxi Yangling 712100，China
OBJECTIVE To investigate the weight-reducing effect of puerarin on obese rats.METHODS After the obese model was built successfully,puerarin was administered intragastrically to obese rats for six weeks.Then,body weight,obese indexes(Lee′s),fat weight around kidneys and testis,fat index(the ratio of fat weight to body weight),adipocyte number,adipocyte size,blood lipid and serum glucose were detected.RESULTS Body weight,obese index,weight of fat tissue,fat index,adipocyte size in the high and low dose of puerarin groups were significantly lower than those in obese model group(P<0.05 or P<0.01).Meanwhile,the levels of serum cholesterol and triglyceride were decreased significantly(P<0.05 or P<0.01).CONCLUSION Administration of puerarin to rats for six weeks shows weight-reducing effect and improved lipid metabolism.
ZHNG Yu-wu;LI Xing-ping;SHENG Fu-wen;SHI Qun-fng;ZHU i-si;HUNG Lu.
Anti-obesity Effect of Puerarin on Diet-induced Obese Rats [J]. Chinese Pharmaceutical Journal, 2008, 43(02): 110-114
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