白术抗炎活性成分的研究

董海燕;董亚琳;贺浪冲;裴渭静

中国药学杂志 ›› 2007, Vol. 42 ›› Issue (14) : 1055-1058.

中国药学杂志
中国药学杂志 ›› 2007, Vol. 42 ›› Issue (14) : 1055-1058.
论著

白术抗炎活性成分的研究

  • 董海燕;董亚琳;贺浪冲;裴渭静
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Studies on Constituents and Anti-Inflammatory Activity of Rhizoma Atractylodis macrocephalae

  • DONG Hai-yan1，DONG Ya-lin1，HE Lang-chong2，PEI Wei-jing3
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摘要

目的对白术(Atractylodes macrocephala Koidz.)的抗炎活性成分进行研究。方法采用正相、反相硅胶柱色谱对白术中的化合物进行分离,依据理化性质、波谱数据分析进行结构鉴定,采用整体动物试验,对各成分进行初步抗炎作用研究,结果从白术中分离鉴定5个化合物,分别为白术内酯Ⅲ(Ⅰ)、白术内酯Ⅰ(Ⅱ)、12-异戊烯酰-14-乙酰-2E,8E,10E-三烯-4,6-二炔-1-醇(Ⅲ)、12-α-甲基丁酰-14-乙酰-2E,8E,10E-三烯-4,6-二炔-1-醇(Ⅳ-1)、12-β-甲基丁酰-14-乙酰-2E,8E,10E-三烯-4,6-二炔-1-醇(Ⅳ-2)。抗炎结果表明,上述各成分对小白鼠急性炎症模型均有一定的抗炎作用。结论白术中含对小白鼠急性炎症模型有一定作用的抗炎活性成分,其中化合物Ⅲ及化合物Ⅳ-1 13C-NMR波谱数据为首次报道。化合物Ⅳ-2数据为首次报道。

Abstract

OBJECTIVE To study the constituents of Atractylodes macrocephala Koidz. and its anti-inflammatory activity.METHODS The chemical components were isolated by silica gel column chromatography. Their structures were identified by spectral analysis. The anti-inflammatory pharmacological experiments of the constituents were carried out in vivo.RESULTS Five compounds were isolated and their structures were established as atractylenolide Ⅲ(Ⅰ), atractylenolideⅠ(Ⅱ), 14-Acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol(Ⅲ), 14-Acet- oxy-12-α-methylbutyl-2E,8E,10E- trien-4,6- diyn-1-ol (Ⅳ-1) and 14-Acet- oxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol(Ⅳ-2). CONCLUSION There are anti-inflammatory constituents in Atractylodes macrocephalae. The 13C-NMR data of compound Ⅲ and Ⅳ-1 are reported for the first time.The data of Ⅳ-2 is reported for the first time.

关键词

白术 / 化学成分 / 抗炎活性

Key words

Atractylodes macrocephala Koidz. / chemical constituents / anti-inflammatory activity

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董海燕;董亚琳;贺浪冲;裴渭静. 白术抗炎活性成分的研究[J]. 中国药学杂志, 2007, 42(14): 1055-1058
DONG Hi-yn;DONG Y-lin;HE Lng-chong;PEI Wei-jing. Studies on Constituents and Anti-Inflammatory Activity of Rhizoma Atractylodis macrocephalae[J]. Chinese Pharmaceutical Journal, 2007, 42(14): 1055-1058

参考文献

[1] Ch.P (2000) Vol Ⅰ (中国药典2000年版. 一部) [S] . 2000： 77. [2] HIKINO H Y，HIKINO I，YOSAHIOKA J，et al.Studies on the constituents of Atractylodes IX. Structure and autoxidation of atractylone[J] .Chem Pharm Bull，1964，12： 755. [3] MARION S L，ALOIS S，RUDOLF B. Diacetoxy-substituted polyacetylenes from Atractylodes lancea[J] .Phytochemistry，1997，46(6)： 1023-1028. [4] HUANG B S，SYN J S，CHEN Z L. Isolation and identification of atractylenolide Ⅳ from Atractylodes macrocephala Koidz.[J] . Acta Bot Sin(植物学报)，1992，34(8)：614-617. [5] CHE Z L. The acetylenes from Atractylodes macrocephala[J] . Planta Medica，1987，53：493-494. [6] CHEN Z L. Chemical constituents of Atractylodes macrocephala Ⅱ.α-methylbutyryl derivatives of Atractylentriol[J] .Acta Chemica Sin(化学学报)，1989：1022-1024.

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