[1] MARKHAM P N，NEYFAKH A A.Efflux-mediated drug resistance in Gram-positive bacteria [J] .Curr Opin Microbiol，2001，4(5)： 509-514. [2] LEWIS K.In search of natural substrates and inhibitors of MDR pumps [J] .J Mol Microbiol Biotechnol，2001，3(2)： 247-254. [3] YU J L，GRINIUS L，HOOPER D C.NorA functions as a multidrug efflux protein in both cytoplasmic membrane vesicles and reconstituted proteoliposomes [J] .J Bacteriol，2002，184(5)： 1370-1377. [4] MARKHAM P N.Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine [J] .Antimicrob Agents Chemother，1999，43(4)： 988-989. [5] TRUONG-BOLDUC Q C，ZHANG X，HOOPER D C. Characterization of NorR protein，a multifunctional regulator of norA expression in Staphylococcus aureus [J] . J Bacteriol，2003，185(10)： 3127-3138. [6] LUONG T T，NEWELL S W，LEE C Y . Mgr，a novel global regulator in Staphylococcus aureus [J] . J Bacteriol，2003，185(13)：3703-3710. [7] FOURNIER B R，ARAS R，HOOPER D C. Expression of the multidrug resistance transporter NorA from Staphylococcus aureus is modified by a two-component regulatory system [J] . J Bacteri，2000，182(3)： 664-671. [8] FOURNIER B R，KLIER A，RAPOPORT G. The two-component system ArlS-ArlR is a regulator of virulence gene expression in Staphylococcus aureus [J] . Mol Microbiol，2001，41(1)：247-261. [9] KAATZ G W，THYAGARAJAN R V，SEO S M. Effect of promoter region mutations and mgrA overexpression on transcription of norA，which encodes a Staphylococcus aureus multidrug efflux transporter [J] . Antimicrob Agents Chemother，2005，49(1)：161-169. [10] KAATZ G W，SEO S M. Effect of substrate exposure and other growth condition manipulations on norA expression [J] . J Antimicrob Chemother，2004，54(2)： 364-369. [11] FERTE J，KUHNEL J M，CHAPUIS G，et al. Flavonoid-related modulators of multidrug resistance： synthesis，pharmacological activity ，and structure-activity relationships [J] . J Med Chem，1999，42(3)： 478-489. [12] GUZ N R，STERMITZ F R，JOHNSON J B，et al. Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump： structure-activity relationships [J] . J Med Chem，2001，44(2)： 261-268. [13] STERMITZ F R，LORENZ P，TAWARA J N，et al. Synergy in a medicinal plant： antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin，a multidrug pump inhibitor [J] . Proc Natl Acad Sci USA，2000，97(4)： 1433-1437. [14] MOREL C，STERMITZ F R，TEGOS G，et al. Isoflavones as potentiators of antibacterial activity [J] . J Agric Food Chem，2003，51(19)： 5677-5679. [15] BELOFSKY G，PERCIVILL D，LEWIS K，et al. Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria [J] . J Nat Prod，2004，67(3)： 481-484. [16] MARKHAM P N，WESTHAUS E，KLYACHKO K. et al. Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus [J] . Antimicrob Agents Chemother，1999，43(10)： 2404-2408. [17] MARKHAM P N，MULHEARN D C，NEYFAKH A A，et al. Inhibitors of multidrug transporters[P] . WO Patent 0032196，2000-06-08. [18] SAMOSORN S，BREMNER J B，BALL A，et al. Synthesis of functionalized 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors [J] . Bioorg Med Chem，2006，14(3)： 857-865. [19] GIBBONS S，OLUWATUYI M，KAATZ G W. A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus [J] . J Antimicrob Chemother，2003，51(1)： 13-17. [20] KAATZ G W，MOUDGAL V V，SEO S M，et al. Phenothiazines and thioxanthenes inhibit multidrug efflux pumpactivity in staphylococcus aureus[J] . Antimicrobial Agent and Chemotherapy，2003，47(2)： 719-726. [21] KAATZ G W，MOUDGAL V V，SEO S M，et al. Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus [J] . Int J Antimicrob Agent，2003，22(3)： 254-261. [22] PEREDA-MIRANDA R，KAATZ G W，GIBBONS S. Polyacylated oligosaccharides from medicinal mexican morning glory species as antibacterials and inhibitors of multidrug resistance in staphylococcus aureus [J] . J Nat Prod，2006，69(3)： 406-409. [23] MARQUEZ B，NEUVILLE L，MOREAU N J，et al. Multidrug resistance reversal agent from Jatropha elliptica[J] . Phytochemistry，2005，66(15)： 1804-1811. [24] MARIA R F，JOSIANE S L，ALDENIR F S，et al. Anti-bacterial activity of some Brazilian medicinal plants[J] . J Ethnopharmacol，2006，105(1-2)： 137-147.