摘要
目的介绍新型抗抑郁药治疗焦虑谱系障碍研究进展。方法在PubMed,Ovid,Springer,Proquest和Elsevier中搜索近期发表的有关文献,对有关资料进行分析。结果与结论抗抑郁药已经成为治疗焦虑谱系障碍的主要手段之一,新型抗抑郁药不但具有抗抑郁和抗焦虑双重药理作用,而且在治疗焦虑方面比传统抗抑郁药及苯二氮类抗焦虑药呈现出更多的优势。选择性5-HT再摄取抑制剂帕罗西汀、氟西汀、氟伏沙明、西酞普兰、艾司西酞普兰、舍曲林及选择性5-HT和NA再摄取抑制剂文拉法辛是治疗焦虑谱系障碍的一线药物,其他新型抗抑郁药如米氮平等治疗焦虑谱系障碍也有较好疗效。
关键词
焦虑谱系障碍 /
抗抑郁药 /
帕罗西汀 /
氟西汀 /
氟伏沙明 /
西酞普兰 /
艾司西酞普兰 /
舍曲林 /
文拉法辛
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翟金国;赵靖平.
新型抗抑郁药治疗焦虑谱系障碍研究进展[J]. 中国药学杂志, 2007, 42(14): 1041-1045
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参考文献
[1] VASILE R G,BRUCE S E,GOISMAN R M,et al.Results of a naturalistic longitudinal study of benzodiazepine and SSRI use in the treatment of generalized anxiety disorder and social phobia[J] . Depress Anxiety,2005,22(2):59-67.
[2] RICKELS K,ZANINELLI R,MCCAFFERTY J,et al. Paroxetine treatment of generalized anxiety disorder: a double-blind,placebo-controlled study[J] . Am J Psychiatry,2003,160(4):749-756.
[3] STOCCHI F,NORDERA G,JOKINEN R,et al. Efficacy and tolerability of paroxetine for the long-term treatment of GAD.In: New Research Abtracts of the 154th Annual Meeting of the American Psychiatric Association[C] .New Orleans,May 9,2001,La.Abstract NR633:171.
[4] VARIA I,RAUSCHER F.Treatment of generalized anxiety disorder with citalopram[J] . Int Clin Psychopharmacol,2002,17(3):103-107.
[5] BIELSKI R J,BOSE A,CHANG C C.A double-blind comparison of escitalopram and paroxetine in the long-term treatment of generalized anxiety disorder[J] . Ann Clin Psychiatry,2005,17(2):65-69.
[6] BALL S G,KUHN A,WALL D,et al.Selective serotonin reuptake inhibitor treatment for generalized anxiety disorder: a double-blind,prospective comparison between paroxetine and sertraline[J] . J Clin Psychiatry,2005,66(1):94-99.
[7] DAVIDSON J R,DUPONT R L,HEDGES D,et al. Efficacy,safety,and tolerability of venlafaxine extended release and buspirone in outpatients with generalized anxiety disorder[J] . J Clin Psychiatry,1999,60(8):528-535.
[8] MONTGOMERY S A,MAHE V,HAUDIQUET V,et al.Effectiveness of venlafaxine,extended release formulation,in the short-term and long-term treatment for generalized anxiety disorder:results of a survival analysis[J] . J Clin Psychopharmacol,2002,22(6):561-567.
[9] STEIN M B,FYER A J,DAVIDSON J R. Fluvoxamine treatment of social phobia (social anxiety disorder): a double-blind,placebo-controlled study[J] . Am J Psychiatry,1999 ,156(5):756-760.
[10] The Research Unit on Pediatric Psychopharmacology Anxiety Study Group. Fluvoxamine for the treatment of anxiety disorders in children and adolescents[J] . N Engl J Med,2001,26(17):1279-1285.
[11] LEPOLA U,BERGTHOLDT B,ST LAMBERT J,et al.Controlled-release paroxetine in the treatment of patients with social anxiety disorder[J] . J Clin Psychiatry,2004,65(2):222-229.
[12] SEEDAT S,STEIN M B.Double-blind,placebo-controlled assessment of combined clonazepam with paroxetine compared with paroxetine monotherapy for generalized social anxiety disorder[J] . J Clin Psychiatry,2004,65(2):244-248.
[13] VAN AMERINGEN M A,LANE R M,WALKER J R,et al. Sertraline treatment of generalized social phobia: a 20-week,double-blind,placebo-controlled study[J] . Am J Psychiatry,2001,158(2):275-281.
[14] WALKER J R,VAN AMERINGEN M A,SWINSON R,et al. Prevention of relapse in generalized social phobia: results of a 24-week study in responders to 20 weeks of sertraline treatment[J] . J Clin Psychopharmacol,2000,20(6):636-644.
[15] CONNOR K M,DAVIDSON J R,CHUNG H,et al.Multidimensional effects of sertraline in social anxiety disorder[J] . Depress Anxiety,2006,23(1):6-10.
[16] SCHNEIER F R,BLANCO C,CAMPEAS R,et al. Citalopram treatment of social anxiety disorder with comorbid major depression[J] . Depress Anxiety,2003,17(4):191-196.
[17] DAVIDSON J R,FOA E B,HUPPERT J D,et al.Fluoxetine,comprehensive cognitive behavioral therapy,and placebo in generalized social phobia[J] . Arch Gen Psychiatry,2004,61(10):1005-1013.
[18] ALTAMURA A C,PIOLI R,VITTO M,et al. Venlafaxine in social phobia: a study in selective serotonin reuptake inhibitor non-responders[J] . Int Clin Psychopharmacol,1999,14(4):239-245.
[19] VAN VEEN J F,VAN VLIET I M,WESTENBERG H G. Mirtazapine in social anxiety disorder: a pilot study[J] . Int Clin Psychopharmacol,2002,17(6):315-317.
[20] TUCKER P,ZANINELLI R,YEHUDA R,et al.Paroxetine in the treatment of chronic posttraumatic stress disorder: results of a placebo-controlled,flexible-dosage trial[J] . J Clin Psychiatry,2001,62(11):860-868.
[21] DAVIDSON J R,ROTHBAUM B O,VAN DER KOLK B A,et al. Multicenter,double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder[J] . Arch Gen Psychiatry,2001,58(5):485-492.
[22] RAPAPORT M H,ENDICOTT J,CLARY C M. Posttraumatic stress disorder and quality of life: results across 64 weeks of sertraline treatment[J] . J Clin Psychiatry,2002,63(1):59-65.
[23] DAVIDSON J,PEARLSTEIN T,LONDBORG P,et al. Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: results of a 28-week double-blind,placebo-controlled study[J] . Am J Psychiatry,2001,158(12):1974-1981.
[24] MARTENYI F,BROWN E B,ZHANG H,et al. Fluoxetine v. placebo in prevention of relapse in post-traumatic stress disorder[J] . Br J Psychiatry,2002,181:315-320.
[25] ONDER E,TURAL U,AKER T. A comparative study of fluoxetine,moclobemide,and tianeptine in the treatment of posttraumatic stress disorder following an earthquake[J] . Eur Psychiatry,2006,21(3): 174-179.
[26] DAVIS L L,FRAZIER E C,WILLIFORD R B,et al. Long-term pharmacotherapy for post-traumatic stress disorder[J] . CNS Drugs,2006,20(6):465-476.
[27] MARTENYI F,SOLDATENKOVA V.Fluoxetine in the acute treatment and relapse prevention of combat-related post-traumatic stress disorder: Analysis of the veteran group of a placebo-controlled,randomized clinical trial[J] . Eur Neuropsychopharmac,2006,16(5):340-349.
[28] ZHAO J P. Clinical Psychopharmacology and Drug Therapy(精神药物治疗学)[M] . Beijing: People's Military Medical Press,2005:299-340.
[29] SHEEHAN D V,BURNHAM D B,IYENGAR M K,et al.Efficacy and tolerability of controlled-release paroxetine in the treatment of panic disorder[J] . J Clin Psychiatry,2005,66(1):34-40.
[30] BERTANI A,PERNA G,MIGLIARESE G,et al. Comparison of the treatment with paroxetine and reboxetine in panic disorder: a randomized,single-blind study[J] . Pharmacopsychiatry,2004,37(5):206-210.
[31] MICHELSON D,ALLGULANDER C,DANTENDORFER K,et al. Efficacy of usual antidepressant dosing regimens of fluoxetine in panic disorder: randomised,placebo-controlled trial[J] . Br J Psychiatry,2001,179:514-518.
[32] RIBEIRO L,BUSNELLO J V,KAUER-SANT'ANNA M,et al. Mirtazapine versus fluoxetine in the treatment of panic disorder[J] . Braz J Med Biol Res,2001,34(10):1303-1307.
[33] ASNIS G M,HAMEEDI F A,GODDARD A W,et al.Fluvoxamine in the treatment of panic disorder: a multi-center,double-blind,placebo-controlled study in outpatients[J] . Psychiatry Res,2001,103(1):1-14.
[34] STAHL S M,GERGEL I,LI D. Escitalopram in the treatment of panic disorder: a randomized,double-blind,placebo-controlled trial[J] . J Clin Psychiatry,2003 ,64(11):1322-1327.
[35] BANDELOW B,BEHNKE K,LENOIR S,et al.Sertraline versus paroxetine in the treatment of panic disorder: an acute,double-blind noninferiority comparison[J] . J Clin Psychiatry,2004 ,65(3):405-413.
[36] BOSHUISEN M L,SLAAP B R,VESTER-BLOKLAND E D,et al. The effect of mirtazapine in panic disorder: an open label pilot study with a single-blind placebo run-in period[J] . Int Clin Psychopharmacol,2001,16(6):363-368.
[37] KAMIJIMA K,MURASAKI M,ASAI M,et al. Paroxetine in the treatment of obsessive-compulsive disorder: randomized,double-blind,placebo-controlled study in Japanese patients[J] . Psychiatry Clin Neuros,2004,58(4):427-433.
[38] MARAZZITI D,GIANNOTTI D,CATENA M C,et al. Insight in body dysmorphic disorder with and without comorbid obsessive-compulsive disorder[J] .CNS Spectr,2006,11(7):494-498.
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脚注
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