摘要
目的分离鉴定地胆草的化学成分,为PC-12细胞活性筛选提供样品。方法用体积分数80%工业酒精提取,硅胶柱色谱分离纯化,根据理化性质和光谱分析确定结构。结果分得8个三萜类成分,分别为无羁萜酮(friedlin,E-6),表无羁萜醇(epifriedlinol,E-7),羽扇豆醇(lupeol,E-8),羽扇豆醇乙酸酯(lupeol acetate,E-9),乌苏酸(ursolic acid,E-10),乌苏-12-烯-3β-十七酸酯(ursa-12-ene-3β-heptadecanoate,E-11),桦木酸(betulinic acid,E-12),30-羟基羽扇豆醇(30-hydroxylupeol,E-13)。结论化合物E-11为一个新的天然产物;化合物E-6,E-10,E-12,E-13为首次从该属植物中得到。
Abstract
OBJECTIVE To elucidate the constituents from the whole plant of Elephantopus scaber and to provide samples for PC-12 cell lines activity screening.METHODS The chromatography on silica gel was used and the structures were determined by IR,NMR and MS spectra analysis and physicochemical properties comparison.RESULTS Eight triterpenes were isolated and identified as friedlin(E-6),epifriedlinol(E-7),lupeol(E-8),lupeol acetate(E-9),ursolic acid(E-10),ursa-12-ene-3β-heptadecanoate(E-11),betulinic acid(E-12),30-hydroxylupeol(E-13).CONCLUSION The compound E-11 is a new nature product and E-6,E-10,E-12 and E-13 are isolated from the genus Elephantopus for the first time.
关键词
地胆草 /
三萜 /
乌苏酸 /
桦木酸
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Key words
Elephantopus scaber /
triterpenes /
ursolic acid /
betulinic acid
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梁侨丽;龚祝南;闵知大.
地胆草三萜成分的研究[J]. 中国药学杂志, 2007, 42(07): 494-496
LING Qio-li;GONG Zhu-nn;MIN Zhi-d.
Studies on Triterpenes from Elephantopus scaber[J]. Chinese Pharmaceutical Journal, 2007, 42(07): 494-496
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参考文献
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脚注
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