摘要
目的综述HIV-1RNase H的生化作用及以该酶为靶点的HIV-1抑制剂的药物设计、构效关系和作用机制等方面的研究进展。方法着重以近几年国外该领域有代表性的文献为依据,进行分析、归纳、总结。结果与结论RNase H在HIV-1逆转录过程中发挥着十分重要的作用,针对该酶所设计的抑制剂,可有效地抑制HIV-1的复制,因此HIV-1RNase H是抗艾滋病治疗中的一个有潜力的药物作用靶点。
关键词
HIV-1RNaseH /
抑制剂 /
研究进展
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于芳;刘新泳.
HIV-1核糖核酸酶H抑制剂的研究进展[J]. 中国药学杂志, 2007, 42(07): 481-486
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脚注
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基金
国家自然科学基金资助项目(30371686);国际合作重点项目(2003DF000033);山东省自然科学基金资助(Y2003C11);山东省1020工程计划资助项目(卫2004-15)
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