OBJECTIVE To prepare protein loaded particles for administration via pulmonary delivery by spray freeze drying.METHODS Interferon α-2b was chosen as a model protein,and mannitol or lactose was used as main excipients.The particle size,morphology,density and hygroscopicity of obtained products were evaluated.And the deposition of interferon DPIs in vitro was determined using a twin stage impinger.RESULTS Spray freeze drying produced large porous particles with ultra low tap density(0.016 g·cm-3) which possessed high in vitro deposition(up to 38.5%).CONCLUSION Spray freeze drying produce protein particles with ultra low density suitable for inhalation.
JING Rong-go;LIU Heng;WNG Li-qing;GUO Hong;WNG Chun-long.
Preparation of Ultra Low Density Interferon α-2b Powder for Inhalation by Spray Freeze Drying [J]. Chinese Pharmaceutical Journal, 2007, 42(05): 362-364
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